Li, X., Hua, T., Vemuri, K., Ho, J.-H., Wu, Y., Wu, L., Popov, P., Benchama, O., Zvonok, N., Locke, K.a., Qu, L., Han, G.W., Iyer, M.R., Cinar, R., Coffey, N.J., Wang, J., Wu, M., Katritch, V., Zhao, S., Kunos, G., Bohn, L.M., Makriyannis, A., Stevens, R.C., and Liu, Z.-J. (2019). Crystal Structure of the Human Cannabinoid Receptor CB2. Cell 176, 459-467.e413.

Tan, F., Chu, C., Qi, J., Li, W., You, D., Li, K., Chen, X., Zhao, W., Cheng, C., Liu, X., Qiao, Y., Su, B., He, S., Zhong, C., Li, H., Chai, R., and Zhong, G. (2019). AAV-ie enables safe and efficient gene transfer to inner ear cells. Nature Communications 10, 3733.

Liu, Y., Qi, J., Chen, X., Tang, M., Chu, C., Zhu, W., Li, H., Tian, C., Yang, G., Zhong, C., Zhang, Y., Ni, G., He, S., Chai, R., and Zhong, G. (2019). Critical role of spectrin in hearing development and deafness. Science Advances 5, eaav7803.

Claff, T., Yu, J., Blais, V., Patel, N., Martin, C., Wu, L., Han, G.W., Holleran, B.J., Van der Poorten, O., White, K.L., Hanson, M.A., Sarret, P., Gendron, L., Cherezov, V., Katritch, V., Ballet, S., Liu, Z.-J., Müller, C.E., and Stevens, R.C. (2019). Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. Science Advances 5, eaax9115.

Qu, L., Zhou, Q., Xu, Y., Guo, Y., Chen, X., Yao, D., Han, G.W., Liu, Z.-J., Stevens, R.C., Zhong, G., Wu, D., and Zhao, S. (2019). Structural Basis of the Diversity of Adrenergic Receptors. Cell Reports 29, 2929-2935.e2924.

Chen, X., Xu, Y., Qu, L., Wu, L., Han, G.W., Guo, Y., Wu, Y., Zhou, Q., Sun, Q., Chu, C., Yang, J., Yang, L., Wang, Q., Yuan, S., Wang, L., Hu, T., Tao, H., Sun, Y., Song, Y., Hu, L., Liu, Z.-J., Stevens, R.C., Zhao, S., Wu, D., and Zhong, G. (2019). Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2A Adrenergic Receptor. Cell Reports 29, 2936-2943.e2934.

Lu, Y., Qin, S., Zhang, B., Dai, A., Cai, X., Ma, M., Gao, Z.-G., Yang, D., Stevens, R.C., Jacobson, K.A., Wang, M.-W., and Shui, W. (2019). Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor. Analytical Chemistry 91, 8162-8169.

Zhou, F., Ding, K., Zhou, Y., Liu, Y., Liu, X., Zhao, F., Wu, Y., Zhang, X., Tan, Q., Xu, F., Tan, W., Xiao, Y., Zhao, S., and Tao, H. (2019). Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor. Journal of Medicinal Chemistry 62, 9983-9989.

Xia, L., Ma, Z., Tong, J., Tang, Y., Li, S., Qin, S., Lou, R., Zhao, S., Lei, X., and Shui, W. (2019). Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry. Analytica Chimica Acta.

Xue, D., Xu, T., Wang, H., Wu, M., Yuan, Y., Wang, W., Tan, Q., Zhao, F., Zhou, F., Hu, T., Jiang, Z., Liu, Z.-J., Zhao, S., Liu, D., Wüthrich, K., and Tao, H. (2019). Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins. Chemistry – A European Journal 25, 11635-11640.

Qi, J., Liu, Y., Chu, C., Chen, X., Zhu, W., Shu, Y., He, S., Chai, R., and Zhong, G. (2019). A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells. Cell Discovery 5, 12.

Zhao, S., Wu, B., and Stevens, R.C. (2019). Advancing Chemokine GPCR Structure Based Drug Discovery. Structure 27, 405-408.

Wu, M., Sun, L., Zhou, Q., Peng, Y., Liu, Z., and Zhao, S. (2019). Molecular Mechanism of Acetate Transport through the Acetate Channel SatP. Journal of Chemical Information and Modeling 59, 2374-2382.

Xue, D., Wang, J., Song, X., Wang, W., Hu, T., Ye, L., Liu, Y., Zhou, Q., Zhou, F., Jiang, Z.-X., Liu, Z.-J., and Tao, H. (2019). A Chemical Strategy for Amphiphile Replacement in Membrane Protein Research. Langmuir 35, 4319-4327.

Xue, D., Ye, L., Zheng, J., Wu, Y., Zhang, X., Xu, Y., Li, T., Stevens, R.C., Xu, F., Zhuang, M., Zhao, S., Zhao, F., and Tao, H. (2019). The structure-based traceless specific fluorescence labeling of the smoothened receptor. Organic & Biomolecular Chemistry 17, 6136-6142.

Hu, W., Wang, H., Hou, Y., Hao, Y., and Liu, D. (2019). Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein-coupled receptors. FEBS Letters 593, 1113-1121.

Wu, Y., Tong, J., Ding, K., Zhou, Q., and Zhao, S. (2019). GPCR Allosteric Modulator Discovery. In Protein Allostery in Drug Discovery, J. Zhang, and R. Nussinov, eds. (Singapore: Springer Singapore), pp. 225-251.

Li, Z., Li, Y., Tang, Y.J., and Shui, W. (2019). Exploiting High-Resolution Mass Spectrometry for Targeted Metabolite Quantification and 13C-Labeling Metabolism Analysis. In Microbial Metabolomics: Methods and Protocols, E.E.K. Baidoo, ed. (New York, NY: Springer New York), pp. 171-184.

Fan, K.-q., Li, Y.-y., Wang, H.-l., Mao, X.-t., Guo, J.-x., Wang, F., Huang, L.-j., Li, Y.-n., Ma, X.-y., Gao, Z.-j., Chen, W., Qian, D.-d., Xue, W.-j., Cao, Q., Zhang, L., Shen, L., Zhang, L., Tong, C., Zhong, J.-y., Lu, W., Lu, L., Ren, K.-m., Zhong, G., Wang, Y., Tang, M., Feng, X.-H., Chai, R.-j., and Jin, J. (2019). Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior. Cell 179, 864-879.e819.

Zhang, B., Li, J., Yang, X., Wu, L., Zhang, J., Yang, Y., Zhao, Y., Zhang, L., Yang, X., Yang, X., Cheng, X., Liu, Z., Jiang, B., Jiang, H., Guddat, L.W., Yang, H., and Rao, Z. (2019). Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell 176, 636-648.e613.

Munk, C., Mutt, E., Isberg, V., Nikolajsen, L.F., Bibbe, J.M., Flock, T., Hanson, M.A., Stevens, R.C., Deupi, X., and Gloriam, D.E. (2019). An online resource for GPCR structure determination and analysis. Nature Methods 16, 151-162.

Yu, X., Li, W., Ma, Y., Tossell, K., Harris, J.J., Harding, E.C., Ba, W., Miracca, G., Wang, D., Li, L., Guo, J., Chen, M., Li, Y., Yustos, R., Vyssotski, A.L., Burdakov, D., Yang, Q., Dong, H., Franks, N.P., and Wisden, W. (2019). GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nature Neuroscience 22, 106-119.

Su, X.-Y., Chen, M., Yuan, Y., Li, Y., Guo, S.-S., Luo, H.-Q., Huang, C., Sun, W., Li, Y., Zhu, M.X., Liu, M.-G., Hu, J., and Xu, T.-L. (2019). Central Processing of Itch in the Midbrain Reward Center. Neuron 102, 858-872.e855.

Lu, Y., Qiu, Y., Chen, P., Chang, H., Guo, L., Zhang, F., Ma, L., Zhang, C., Zheng, X., Xiao, J., Zhong, R., Han, L., Xu, X., Zhang, Y., Li, D., Zhong, G., Boyton, R., Huang, Y., He, Y., Hu, R., Wei, B., and Wang, H. (2019). ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. Nature Microbiology 4, 2331-2346.

Ma, P., Xu, H., Li, J., Lu, F., Ma, F., Wang, S., Xiong, H., Wang, W., Buratto, D., Zonta, F., Wang, N., Liu, K., Hua, T., Liu, Z.-J., Yang, G., and Lerner, R.A. (2019). Functionality-Independent DNA Encoding of Complex Natural Products. Angewandte Chemie 131, 9355-9362.

Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katritch, V., Cherezov, V., Hanson, M.A., and Stevens, R.C. (2019). Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor. Nature Chemical Biology 15, 11-17.

Yu, J., Liu, Z., Liang, Y., Luo, F., Zhang, J., Tian, C., Motzik, A., Zheng, M., Kang, J., Zhong, G., Liu, C., Fang, P., Guo, M., Razin, E., and Wang, J. (2019). Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells. Nature Communications 10, 4664.

Chen, S., Lu, M., Liu, D., Yang, L., Yi, C., Ma, L., Zhang, H., Liu, Q., Frimurer, T.M., Wang, M.-W., Schwartz, T.W., Stevens, R.C., Wu, B., Wüthrich, K., and Zhao, Q. (2019). Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography. Nature Communications 10, 638.

Jia, Z., Yan, L., Ren, Z., Wu, L., Wang, J., Guo, J., Zheng, L., Ming, Z., Zhang, L., Lou, Z., and Rao, Z. (2019). Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis. Nucleic Acids Research 47, 6538-6550.

Yuan, Y., Wu, W., Chen, M., Cai, F., Fan, C., Shen, W., Sun, W., and Hu, J. (2019). Reward Inhibits Paraventricular CRH Neurons to Relieve Stress. Current Biology 29, 1243-1251.e1244.

Hao, K., Lei, W., Wu, H., Wu, J., Yang, Z., Yan, S., Lu, X.-A., Li, J., Xia, X., Han, X., Deng, W., Zhong, G., Zhao, Z.-A., and Hu, S. (2019). LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction. Theranostics 9, 7282-7297.

Ye, M., Xu, B.-B., Zhang, R., Yang, Y.-N., Yang, L.-Y., Wang, X.L., and Yao, Y.-F. (2019). Probing the methanol heterogeneous photochemistry processes by operando NMR – The role of bulk water. Journal of Catalysis 378, 36-41.

Song, X., Shan, H., Zhu, Y., Hu, S., Xue, L., Chen, Y., Ding, W., Niu, T., Gu, J., Ouyang, S., Shen, Q.-T., and Liu, Z.-J. (2019). Self-capping of nucleoprotein filaments protects the Newcastle disease virus genome. eLife 8, e45057.

Lu, L., Guo, Y., Wang, T., Liang, L., Zhao, S., Wang, F., and Liu, L. (2019). Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop. Science China Chemistry.

Kong, D., Xue, T., Guo, B., Cheng, J., Liu, S., Wei, J., Lu, Z., Liu, H., Gong, G., Lan, T., Hu, W., and Yang, Y. (2019). Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. Journal of Medicinal Chemistry 62, 3088-3106.

Gao, S., Guo, X., Zhao, S., Jin, Y., Zhou, F., Yuan, P., Cao, L., Wang, J., Qiu, Y., Sun, C., Kang, Z., Gao, F., Xu, W., Hu, X., Yang, D., Qin, Y., Ning, K., Shaw, P.J., Zhong, G., Cheng, L., Zhu, H., Gao, Z., Chen, X., and Xu, J. (2019). Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury. Cell Death & Disease 10, 597.

Li, F., Jiang, X., Luo, L.-L., Xu, Y.-M., Huang, X.-X., Huang, C., and Zhang, Y. (2019). A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells. Cell Communication and Signaling 17, 49.

Zhou, H., Zhang, S., Lv, F., Sun, W., Wang, L., Fan, C., Li, J., and Hu, J. (2019). Citrate-assisted efficient local delivery of naked oligonucleotide into live mouse brain cells. Cell Proliferation 52, e12622.

Zhang, G., McCorvy, J.D., Shen, S., Cheng, J., Roth, B.L., and Kozikowski, A.P. (2019). Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism. European Journal of Medicinal Chemistry 182, 111626.

Xu, Y., Wang, Y., Wang, Y., Liu, K., Peng, Y., Yao, D., Tao, H., Liu, H., and Song, G. (2019). Mutagenesis facilitated crystallization of GLP-1R. IUCrJ 6, 996-1006.

Li, X., Diao, M., Zhang, Y., Chen, G., Huang, S., and Chen, N. (2019). Guard Cell Microfilament Analyzer Facilitates the Analysis of the Organization and Dynamics of Actin Filaments in Arabidopsis Guard Cells. International Journal of Molecular Sciences 20, 2753.

Wang, Z., Liang, H., Cao, H., Zhang, B., Li, J., Wang, W., Qin, S., Wang, Y., Xuan, L., Lai, L., and Shui, W. (2019). Efficient ligand discovery from natural herbs by integrating virtual screening, affinity mass spectrometry and targeted metabolomics. Analyst 144, 2881-2890.

Laprairie, R.B., Vemuri, K., Stahl, E.L., Korde, A., Ho, J.-H., Grim, T.W., Hua, T., Wu, Y., Stevens, R.C., Liu, Z.-J., Makriyannis, A., and Bohn, L.M. (2019). Probing the CB1 cannabinoid receptor binding pocket with AM6538, a high-affinity irreversible antagonist. Molecular Pharmacology, mol.119.116483.

Chen, P., Jiao, X., Zhang, Y., Wu, L., Tang, D.-J., Li, P., Chen, X., Chao, D., Tang, J.-L., and Ming, Z. (2019). The crystal structure of the phytopathogenic bacterial sensor PcrK reveals different cytokinin recognition mechanism from the plant sensor AHK4. Journal of Structural Biology 208, 69-76.

Zhang, R., Xu, X., Cao, H., Yuan, C., Yuminaga, Y., Zhao, S., Shi, J., and Zhang, B. (2019). Purification, characterization, and application of a high activity 3-ketosteroid-Δ1-dehydrogenase from Mycobacterium neoaurum DSM 1381. Applied Microbiology and Biotechnology 103, 6605-6616.

Zhang, S., Lv, F., Yuan, Y., Fan, C., Li, J., Sun, W., and Hu, J. (2019). Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons. Frontiers in Neuroscience 13.

Diao, M., Li, X., and Huang, S. (2019). Arabidopsis AIP1-1 regulates the organization of apical actin filaments by promoting their turnover in pollen tubes. Science China Life Sciences.

Ai, H., Guo, Y., Sun, D., Liu, S., Qi, Y., Guo, J., Qu, Q., Gong, Q., Zhao, S., Li, J., and Liu, L. (2019). Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones. ChemBioChem 20, 221-229.

Zhao, H., Chen, L., Zhong, G., Huang, Y., Zhang. X,. Chu, C., Chen, L., Wang, M.(2019) Titanium Dioxide Nanoparticles Induce Mitochondrial Dynamic Imbalance and Damage in HT22 Cells. Journal of Nanomaterials 2019, 16.

Diao, M., Wang, Q., and Huang, S. (2019). Quantitative Plasmodesmata Permeability Assay for Pavement Cells of Arabidopsis Leaves. Bio-protocol 9, e3206.

Abernathy, M., Wan, N., Shui, W., and Tang, Y.J. (2019). Dynamic 13C Labeling of Fast Turnover Metabolites for Analysis of Metabolic Fluxes and Metabolite Channeling. In Microbial Metabolomics: Methods and Protocols, E.E.K. Baidoo, ed. (New York, NY: Springer New York), pp. 301-316.