科学研究

1.       Li, H., Fang, Y., Wang, D., Shi, B., & Thompson, G. J. (2024). Impaired brain glucose metabolism in glucagon-like peptide-1 receptor knockout mice. Nutrition & diabetes, 14(1), 86.

2.       Han, W., Bao, S., Liu, J., Wu, Y., Zeng, L., Zhang, T., Chen, N., Yao, K., Fan, S., Huang, A., Feng, Y., Zhang, G., Zhang, R., Zhu, H., Hua, T., Liu, Z., Cao, L., Huang, X., & Zhao, S. (2024). CORD: The chordata olfactory receptor database. Protein & cell, pwae050. Advance online publication.

3.       Chang, H., Li, X., Shen, L., Ge, X., Hao, S., Wu, L., Liu, S., Liu, J., Cherezov, V., & Hua, T. (2024). Structure basis of ligand recognition and activation of GPR55. Cell research, 10.1038/s41422-024-01046-8. Advance online publication.

4.       Fu, Y., Guo, C. J., Liu, Z. J., & Liu, J. L. (2024). Architecture of CTPS filament networks revealed by cryo-electron tomography. Experimental cell research, 442(2), 114262.

5.       Dang, T., Yu, J., Cao, Z., Zhang, B., Li, S., Xin, Y., Yang, L., Lou, R., Zhuang, M., & Shui, W. (2024). Endogenous cell membrane interactome mapping for the GLP-1 receptor in different cell types. Nature chemical biology, 10.1038/s41589-024-01714-1. Advance online publication.

6.       Liu, H., Yan, P., Zhang, Z., Han, H., Zhou, Q., Zheng, J., Zhang, J., Xu, F., & Shui, W. (2024). Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor. Journal of the American Chemical Society, 146(29), 20045–20058.

7.       Jiang, K., Zheng, Y., Zeng, L., Wang, L., Li, F., Pu, J., Lu, Y., Zhao, S., & Xu, F. (2024). The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell reports, 43(7), 114505. 

8.       Zhang, Z., Zheng, Y., Xu, L., Yue, Y., Xu, K., Li, F., & Xu, F. (2024). Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15. Cell discovery, 10(1), 69.

9.       Yan, P., Lin, X., Wu, L., Xu, L., Li, F., Liu, J., & Xu, F. (2024). The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer. Nature communications, 15(1), 5255.

10.     Tsuchitani, T., Tomaru, A., Aoki, Y., Ishiguro, N., Tsuda, Y., & Sugiyama, Y. (2024). Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target-mediated drug disposition and OATP1B3-mediated hepatic uptake in a physiologically based model. CPT: pharmacometrics & systems pharmacology, 13(7), 1224–1237.

11.     Wang, T., Tang, W., Zhu, X., Lv, Z., Chen, J., Li, Y., Sun, X., Lv, H., Gu, Q., Li, F., & Wang, J. (2024). Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1. Cell research, 34(8), 590–593.

12.     Hu, X., Ao, W., Gao, M., Wu, L., Pei, Y., Liu, S., Wu, Y., Zhao, F., Sun, Q., Liu, J., Jiang, L., Wang, X., Li, Y., Tan, Q., Cheng, J., Yang, F., Yang, C., Sun, J., Hua, T., & Liu, Z. J. (2024). Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631(8020), 459–466.

13.     Zeng, Y. F., Yang, K. X., Cui, Y., Zhu, X. N., Li, R., Zhang, H., Wu, D. C., Stevens, R. C., Hu, J., & Zhou, N. (2024). Conjunctive encoding of exploratory intentions and spatial information in the hippocampus. Nature communications, 15(1), 3221.

14.     Li, H., Ye, Q., Wang, D., Shi, B., Xu, W., Zhang, S., Han, X., Zhang, X. Y., & Thompson, G. J. (2024). Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1. ACS chemical neuroscience, 15(8), 1669–1683.

15.     Pan, B., Guo, C., Liu, D., & Wüthrich, K. (2024). Fluorine-19 labeling of the tryptophan residues in the G protein-coupled receptor NK1R using the 5-fluoroindole precursor in Pichia pastoris expression. Journal of biomolecular NMR, 78(3), 133–138.

16.     Li, H., & Cheng, J. (2024). 2-Phenylcyclopropylmethylamine (PCPMA) as a privileged scaffold for central nervous system drug design. Bioorganic & medicinal chemistry letters, 101, 129654. 

17.     Wang, D., Li, H., Xu, M., Bo, B., Pei, M., Liang, Z., & Thompson, G. J. (2024). Differential Effect of Global Signal Regression Between Awake and Anesthetized Conditions in Mice. Brain connectivity, 14(1), 48–59.

18.     Li, W., Li, A., Yu, B., Zhang, X., Liu, X., White, K. L., Stevens, R. C., Baumeister, W., Sali, A., Jasnin, M., & Sun, L. (2024). In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography. Nature communications, 15(1), 1311. 

19.     Jiang, S., Lin, X., Wu, L., Wang, L., Wu, Y., Xu, Z., & Xu, F. (2024). Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Science advances, 10(5), eadj7500.

20.     Zhang, Z., Lin, X., Wei, L., Wu, Y., Xu, L., Wu, L., Wei, X., Zhao, S., Zhu, X., & Xu, F. (2024). A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell discovery, 10(1), 3.

21.     Liu, R., Duan, W., Yan, W., Zhang, J., Cheng, J. (2024). Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A 2A adenosine receptors and histone deacetylases. Chinese chemical letters, 35(1).

22.     Yin, Y., Wang, H., Yang, Y., Hai, X., Li, Z., Ren, C., Huai, P. (2024). Surface properties of non-passivated nickel-based alloys in H2O-bearing environments by theoretical calculations: Atomic modification effects from alloying additions. Journal of applied physics. 135(20).

23.     Lao, Y., Cui, X., Xu, Z., Yan, H., Zhang, Z., Zhang, Z., Geng, L., Li, B., Lu, Y., Guan, Q., Pu, X., Zhao, S., Zhu, J., Qin, X., & Sun, B. (2024). Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma. Journal of hepatology, 81(5), 847–861.

24.     Fan, L., Zhuang, Y., Wu, H., Li, H., Xu, Y., Wang, Y., He, L., Wang, S., Chen, Z., Cheng, J., Xu, H. E., & Wang, S. (2024). Structural basis of psychedelic LSD recognition at dopamine D₁ receptor. Neuron, 112(19), 3295–3310.e8.

25.     Nakamura, R., Yoshikado, T., Aoki, Y., Sugiyama, Y., & Chiba, K. (2024). Elucidation of DPP-4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method. Clinical and translational science, 17(10), e70047.

26.     Wąsińska-Kałwa, M., Omran, A., Mach, L., Scipioni, L., Bouma, J., Li, X., Radetzki, S., Mostinski, Y., Schippers, M., Gazzi, T., van der Horst, C., Brennecke, B., Hanske, A., Kolomeets, Y., Guba, W., Sykes, D., von Kries, J. P., Broichhagen, J., Hua, T., Veprintsev, D., … Nazare, M. (2024). Visualization of membrane localization and the functional state of CB₂R pools using matched agonist and inverse agonist probe pairs. Chemical science, 15(44), 18443–18454. Advance online publication.

27.     Gao, J., Wang, D., Zhu, C., Wang, J., Wang, T., Xu, Y., Ren, X., Zhang, K., Peng, C., Guan, J., & Wang, Y. (2024). H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice. The journal of headache and pain, 25(1), 163.

28.     Liu, Z., Zhang, H., Lu, K., Chen, L., Zhang, Y., Xu, Z., Zhou, H., Sun, J., Xu, M., Ouyang, Q., Thompson, G. J., Yang, Y., Su, N., Cai, X., Cao, L., Zhao, Y., Jiang, L., Zheng, Y., & Zhang, X. (2024). Low-intensity pulsed ultrasound modulates disease progression in the SOD1^G93A mouse model of amyotrophic lateral sclerosis. Cell reports, 43(9), 114660.

29.     Fan, M., Fan, X., Lai, Y., Chen, J., Peng, Y., Peng, Y., Xiang, L., & Ma, Y. (2024). Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives. Frontiers in immunology, 15, 1448952.

30.     Qian, Y., Ma, Z., Xu, Z., Duan, Y., Xiong, Y., Xia, R., Zhu, X., Zhang, Z., Tian, X., Yin, H., Liu, J., Song, J., Lu, Y., Zhang, A., Guo, C., Jin, L., Kim, W. J., Ke, J., Xu, F., Huang, Z., & He, Y. (2024). Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation. Nature communications, 15(1), 7644.

31.     Zhang, K., Wan, P., Wang, L., Wang, Z., Tan, F., Li, J., Ma, X., Cen, J., Yuan, X., Liu, Y., Sun, Z., Cheng, X., Liu, Y., Liu, X., Hu, J., Zhong, G., Li, D., Xia, Q., & Hui, L. (2024). Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases. Cell stem cell, 31(8), 1187–1202.e8.

32.     Hou, J., Liu, S., Zhang, X., Tu, G., Wu, L., Zhang, Y., Yang, H., Li, X., Liu, J., Jiang, L., Tan, Q., Bai, F., Liu, Z., Miao, C., Hua, T., & Luo, Z. (2024). Structural basis of antagonist selectivity in endothelin receptors. Cell discovery, 10(1), 79.

33.     Aoki, Y., Rowland, M., & Sugiyama, Y. (2024). When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement. Frontiers in pharmacology, 15, 1366160. 

34.     Weiss, H. M., Sugiyama, Y., & van Duijn, E. (2024). Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development. Frontiers in pharmacology, 15, 1455643.

35.     Mach, L., Omran, A., Bouma, J., Radetzki, S., Sykes, D. A., Guba, W., Li, X., Höffelmeyer, C., Hentsch, A., Gazzi, T., Mostinski, Y., Wasinska-Kalwa, M., de Molnier, F., van der Horst, C., von Kries, J. P., Vendrell, M., Hua, T., Veprintsev, D. B., Heitman, L. H., Grether, U., … Nazare, M. (2024). Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB₁R). Journal of medicinal chemistry, 67(14), 11841–11867.

36.     Cheng, P., Mao, C., Tang, J., Yang, S., Cheng, Y., Wang, W., Gu, Q., Han, W., Chen, H., Li, S., Chen, Y., Zhou, J., Li, W., Pan, A., Zhao, S., Huang, X., Zhu, S., Zhang, J., Shu, W., & Wang, S. (2024). Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering. Cell research, 34(9), 630–647.

37.     Wang, C., Hai, X., Wang, H., Song, Y., Wan, Z., Yang, Y., Huai, P., Yin, Y. (2024).  Synergetic Effects of Strain Engineering and Carbon Vacancy Modification on Ti_n+1C_nO₂ MXene for Promising Catalytic Activity of Hydrogen Evolution Reaction. Journal of physical chemistry c, 128(25), 10324-10335

38.     Li, T., Liu, M., Gu, Z., Su, X., Liu, Y., Lin, J., Zhang, Y., & Shen, Q. T. (2024). Structures of the mumps virus polymerase complex via cryo-electron microscopy. Nature communications, 15(1), 4189.

39.     Liu, M., Liu, Y., Song, T., Yang, L., Qi, L., Zhang, Y. Z., Wang, Y., & Shen, Q. T. (2024). Three-dimensional architecture of ESCRT-III flat spirals on the membrane. Proceedings of the National Academy of Sciences of the United States of America, 121(20), e2319115121.

40.     Jiang, L., Yang, Y., Huang, L., Zhou, Y., An, J., Zheng, Y., Chen, Y., Liu, Y., Huang, J., Ang, E., Zhao, S., Zhao, H., Liao, R., Wei, Y., Zhang, Y. (2024). Glycyl Radical Enzymes Catalyzing the Dehydration of Two Isomers of N-Methyl-4-hydroxyproline. Acs catalysis. 14(7), 4407-4422

41.     Chen, Z., Yu, J., Wang, H., Xu, P., Fan, L., Sun, F., Huang, S., Zhang, P., Huang, H., Gu, S., Zhang, B., Zhou, Y., Wan, X., Pei, G., Xu, H. E., Cheng, J., & Wang, S. (2024). Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187(9), 2194–2208.e22.

42.     Wang, W., Xi, H., Fu, D., Ma, D., Gong, W., Zhao, Y., Li, X., Wu, L., Guo, Y., Zhao, G., & Wang, H. (2024). Growth Process of Fe-O Nanoclusters with Different Sizes Biosynthesized by Protein Nanocages. Journal of the American Chemical Society, 146(17), 11657–11668. 

43.     Fu, Y., Yu, Y., Wang, Y., Sun, Y., Zhang, K., Xu, F., Wang, N., Wang, B., & Lu, Y. (2024). Nonlinear relationship between body mass index and serum uric acid: An observational and Mendelian randomization study among Chinese adults. Nutrition, metabolism, and cardiovascular diseases : NMCD, 34(4), 998–1007.

44.     Fu, Y., Lu, M., Zhang, K., Sun, Y., Tan, X., Wang, N., Xu, F., Jiang, B., Lu, Y., & Wang, B. (2024). Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Type 2 Diabetes: A Prospective Cohort Study. The Journal of clinical endocrinology and metabolism, 109(9), 2173–2181. 

45.     You, X. M., Xu, B., Zhou, H., Qiao, H., Lv, X., Huang, Z., Pang, J., Yang, L., Liu, P. F., Guan, X., Yang, H. G., Wang, X., & Yao, Y. F. (2024). Ultrahigh Bifunctional Photocatalytic CO₂ Reduction and H₂ Evolution by Synergistic Interaction of Heteroatomic Pt-Ru Dimerization Sites. ACS nano, 18(13), 9403–9412.

46.    张怡; 全枝艳; 楼飞洋; 方玉娇; Garth J.THOMPSON; 陈高; 张孝通。(2024). 一种用于多核磁共振成像及波谱的鸟笼线圈与可更换单环线圈的一体化设计（英文）Journal of Zhejiang University-Science B(Biomedicine & Biotechnology). 25(02), 168-181

47.     Wang, T., Tang, W., Zhao, Z., Zhao, R., Lv, Z., Guo, X., Gu, Q., Liu, B., Lv, H., Chen, J., Zhang, K., Li, F., & Wang, J. (2024). Fenofibrate Recognition and G_q Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(14), e2306311. 

48.     Cai, L., Shen, W., Li, J., Wang, B., Sun, Y., Chen, Y., Gao, L., Xu, F., Xiao, X., Wang, N., & Lu, Y. (2024). Association between glycemia risk index and arterial stiffness in type 2 diabetes. Journal of diabetes investigation, 15(5), 614–622.

49.     Li, F., Tai, L., Sun, X., Lv, Z., Tang, W., Wang, T., Zhao, Z., Gong, D., Ma, S., Tang, S., Gu, Q., Zhu, X., Yu, M., Liu, X., & Wang, J. (2024). Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell research, 34(4), 323–326.

50.     Qi, J., Tan, F., Zhang, L., Zhou, Y., Zhang, Z., Sun, Q., Li, N., Fang, Y., Chen, X., Wu, Y., Zhong, G., & Chai, R. (2024). Critical role of TPRN rings in the stereocilia for hearing. Molecular therapy: the journal of the American Society of Gene Therapy, 32(1), 204–217.