科学研究

Zhou, Y., Xu, X., Wei, Y., Cheng, Y., Guo, Y., Khudyakov, I., Liu, F., He, P., Song, Z., Li, Z., Gao, Y., Ang, E. L., Zhao, H., Zhang, Y., & Zhao, S. (2021). A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science 372(6541), 512–516.

Xu, L., Chen, B., Schihada, H., Wright, S. C., Turku, A., Wu, Y., Han, G., Kowalski-Jahn, M., Kozielewicz, P., Bowin, C., Zhang, X., Li, C., Bouvier, M., Schulte, G., & Xu, F., (2021). Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Cell Research, 31(12), 1311–1314.

Li, S., Luo, H., Lou, R., Tian, C., Miao, C., Xia, L., Pan, C., Duan, X., Dang, T., Li, H., Fan, C., Tang, P., Zhang, Z., Liu, Y., Li, Y., Xu, F., Zhang, Y., Zhong, G., Hu, J., & Shui, W. (2021). Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression. Science advances, 7(30), eabf0634.

 Zheng, Y., Liu, H., Chen, Y., Dong, S., Wang, F., Wang, S., Li, S., Shu, L., & Xu, F. (2022). Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron, 110(2), 237-247.e4. 

 Lou, R., Liu, W., Li, R., Li, S., He, X., & Shui, W. (2021). DeepPhospho accelerates DIA phosphoproteome profiling through in silico library generation. Nature Communications, 12(1), 6685.

Duan, W., Sun, Y., Wu, M., Zhang, Z., Zhang, T., Wang, H., Li, F., Yang, L., Xu, Y., Liu, Z. J., Hua, T., Nie, H., & Cheng, J. (2021). Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis. European journal of medicinal chemistry, 226, 113878. 

  Wu, Y., & Zhao, S. (2020). Furin cleavage sites naturally occur in coronaviruses. Stem cell research, 50, 102115.

 Wang, H., Hu, W., Liu, D., & Wüthrich, K. (2021). Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for 19 F-NMR studies in solution. The FEBS journal, 288(13), 4053–4063. 

 Tong, J., & Zhao, S. (2021). Large-Scale Analysis of Bioactive Ligand Conformational Strain Energy by Ab Initio Calculation. Journal of Chemical Information and Modeling 2021 61 (3), 1180-1192.

 Liu, K., Shen, L., Wu, M., Liu, Z. J., & Hua, T. (2022). Structural insights into the activation of chemokine receptor CXCR2. The FEBS journal, 289(2), 386–393. 

Zhang, N., Shan, H., Liu, M., Li, T., Luo, R., Yang, L., Qi, L., Chu, X., Su, X., Wang, R., Liu, Y., Sun, W., & Shen, Q.-T. (2021). Structure and assembly of double-headed Sendai virus nucleocapsids. Communications Biology, 4(1), 494.

 Lu, Y., Liu, H., Yang, D., Zhong, L., Xin, Y., Zhao, S., Wang, M. W., Zhou, Q., & Shui, W. (2021). Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket. ACS chemical biology, 16(6), 991–1002.

Wu, Y., Zeng, L., & Zhao, S. (2021). Ligands of Adrenergic Receptors: A Structural Point of View.Biomolecules, 11(7), 936.

 Shan, H., Su, X., Li, T., Qin, Y., Zhang, N., Yang, L., Ma, L., Bai, Y., Qi, L., Liu, Y., & Shen, Q.-T. (2021). Structural plasticity of mumps virus nucleocapsids with cryo-EM structures. Communications Biology, 4(1), 833.

Zhao, F., Wu, Y., Zhou, F., Xue, D., Zhao, S., Lu, W., Liu, X., Hu, T., Qiu, Y., Li, R., Gu, T., Xu, Y., Xu, F., Zhong, G., Jiang, Z., Zhao, S., & Tao, H. (2021). Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. Journal of medicinal chemistry, 64(18), 13830–13840.

Hu, T., Zheng, G., Xue, D., Zhao, S., Li, F., Zhou, F., Zhao, F., Xie, L., Tian, C., Hua, T., Zhao, S., Xu, Y., Zhong, G., Liu, Z. J., Makriyannis, A., Stevens, R. C., & Tao, H. (2021). Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools. Journal of medicinal chemistry, 64(18), 13752–13765.

Wang, X., Liu, D., Shen, L., Li, F., Li, Y., Yang, L., Xu, T., Tao, H., Yao, D., Wu, L., Hirata, K., Bohn, L. M., Makriyannis, A., Liu, X., Hua, T., Liu, Z. J., & Wang, J. (2021). A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1. Journal of the American Chemical Society, 143(40), 16320–16325.

Liu, Y., Zhou, F., Ding, K., Xue, D., Zhu, Z., Li, C., Li, F., Xu, Y., Xu, F., Le, Z., Zhao, S., Tao, H.(2021). Structure-Activity Relationship Studies of Hydantoin-Cored Ligands for Smoothened Receptor. ChemistryOpen.

Raveh, B., Sun, L., White, K. L., Sanyal, T., Tempkin, J., Zheng, D., Bharath, K., Singla, J., Wang, C., Zhao, J., Li, A., Graham, N. A., Kesselman, C., Stevens, R. C., & Sali, A. (2021). Bayesian metamodeling of complex biological systems across varying representations. Proceedings of the National Academy of Sciences of the United States of America, 118(35), e2104559118.

Lin, Y., Hu, Q., Zhou, J., Yin, W., Yao, D., Shao, Y., Zhao, Y., Guo, B., Xia, Y., Chen, Q., Wang, Y., Ye, W., Xie, Q., Tyler, B. M., Xing, W., & Wang, Y. (2021). Phytophthora sojae effector Avr1d functions as an E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection. Proceedings of the National Academy of Sciences of the United States of America, 118(10), e2018312118.

Zhang, X., He, C., Wang, M., Zhou, Q., Yang, D., Zhu, Y., Feng, W., Zhang, H., Dai, A., Chu, X., Wang, J., Yang, Z., Jiang, Y., Sensfuss, U., Tan, Q., Han, S., Reedtz-Runge, S., Xu, H. E., Zhao, S., Wang, M. W., … Zhao, Q. (2021). Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nature chemical biology, 17(12), 1230–1237.

Amporndanai, K., Meng, X., Shang, W., Jin, Z., Rogers, M., Zhao, Y., Rao, Z., Liu, Z. J., Yang, H., Zhang, L., O'Neill, P. M., & Samar Hasnain, S. (2021). Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nature communications, 12(1), 3061.

Song, X., Shi, Y., Ding, W., Niu, T., Sun, L., Tan, Y., Chen, Y., Shi, J., Xiong, Q., Huang, X., Xiao, S., Zhu, Y., Cheng, C., Fu, Z. F., Liu, Z. J., & Peng, G. (2021). Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes. Nature communications, 12(1), 141.

Xu, L., Tong, J., Wu, Y., Zhao, S., & Lin, B. L. (2021). A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues. Biophysical chemistry, 276, 106610.

Xie, G., Jiang, R., Wang, X., Liu, P., Zhao, A., Wu, Y., Huang, F., Liu, Z., Rajani, C., Zheng, X., Qiu, J., Zhang, X., Zhao, S., Bian, H., Gao, X., Sun, B., & Jia, W. (2021). Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis. EBioMedicine, 66, 103290.

Zhu, C., Liu, W., Zhao, F., Chen, Y., Tao, H., He, Y. P., & Yang, X. (2021). Kinetic Resolution of 2,2-Disubstituted Dihydroquinolines through Chiral Phosphoric Acid-Catalyzed C6-Selective Asymmetric Halogenations. Organic letters, 23(11), 4104–4108.

He, F., Wang, J., Zhou, F., Tao, H., & Yang, X. (2021). Regio- and enantioselective amination of acyclic branched α-alkynyl ketones: asymmetric construction of N-containing quaternary stereocenters. Organic Chemistry Frontiers, 8(19), 5377–5382.

Tian, X., Zhang, X., Hou, X., Ren, W., Li, X., Zhao, F., Tao, H., Wang, Y. (2021). Formal [4+1] Cyclization of ortho- or para-Quinone Methides with 3-Chlorooxindoles: Synthesis of 3,2′-Tetrahydrofuryl Spirooxindoles. ASIAN JOURNAL OF ORGANIC CHEMISTRY.

Yang, D., Zhou, Q., Labroska, V., Qin, S., Darbalaei, S., Wu, Y., Yuliantie, E., Xie, L., Tao, H., Cheng, J., Liu, Q., Zhao, S., Shui, W., Jiang, Y., & Wang, M.-W. (2021). G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduction and Targeted Therapy, 6(1), 7.

Deng, Y., Yu, Y., Shi, B., Bao, M., Zhao, S., Cai, X. (2021). Monoterpenoid Indole Alkaloids with Promoting Neurite Growth from Tabernaemontana divaricate. Chinese Journal of Chemistry. 

Zhou, Q., Guo, W., Dai, A., Cai, X., Vass, M., de Graaf, C., Shui, W., Zhao, S., Yang, D., & Wang, M. W. (2021). Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening. Biomolecules, 11(7), 929.

Martin, C., Gimenez, L. E., Williams, S. Y., Jing, Y., Wu, Y., Hollanders, C., Van der Poorten, O., Gonzalez, S., Van Holsbeeck, K., Previti, S., Lamouroux, A., Zhao, S., Tourwé, D., Stevens, R. C., Cone, R. D., & Ballet, S. (2021). Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure. Journal of medicinal chemistry, 64(1), 357–369.

Jiang, S., Iliopoulos-Tsoutsouvas, C., Tong, F., Brust, C. A., Keenan, C. M., Raghav, J. G., Hua, T., Wu, S., Ho, J. H., Wu, Y., Grim, T. W., Zvonok, N., Thakur, G. A., Liu, Z. J., Sharkey, K. A., Bohn, L. M., Nikas, S. P., & Makriyannis, A. (2021). Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists. Journal of medicinal chemistry, 64(7), 3870–3884.

Xu, B. B., Zhou, M., Ye, M., Yang, L. Y., Wang, H. F., Wang, X. L., & Yao, Y. F. (2021). Cooperative Motion in Water-Methanol Clusters Controls the Reaction Rates of Heterogeneous Photocatalytic Reactions. Journal of the American Chemical Society, 143(29), 10940–10947.

Zhang, L., Yao, D., Xia, Y., Zhou, F., Zhang, Q., Wang, Q., Qin, A., Zhao, J., Li, D., Li, Y., Zhou, L., & Cao, Y. (2021). The structural basis for glycerol permeation by human AQP7. Science Bulletin, 66(15), 1550–1558.

Wang, J., Li, L., Ming, Z., Wu, L., & Yan, L. (2021). Crystal Structure of the Epo1-Bem3 Complex for Bud Growth. International journal of molecular sciences, 22(8), 3812.

Liu, F., Su, Z., Chen, P., Tian, X., Wu, L., Tang, D. J., Li, P., Deng, H., Ding, P., Fu, Q., Tang, J. L., & Ming, Z. (2021). Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator. Nucleic acids research, 49(11), 6511–6528.

Qian, J., Wang, Y., Pan, J., Chen, Z., Chen, J., Lin, J., Chen, F.& Yang, Y. (2021). Trace detection based on quantum dots embedded in the biocarbon with multi-scale pores. Applied Surface Science, 535, 147758.

Ni, H., Arslan, M., Qian, J., Wang, Y., Liu, Z., Luo, Z., Cai, R., El-Din, M. & Wu, Z. (2021). Application of basalt fibers in a biological contact oxidation reactor for the treatment of landfill leachate. Journal of Cleaner Production, 297, 126648.

Lin, J., Qian, J., Wang, Y., Yang, Y., Zhang, Y., Chen, J., Chen, X. & Chen, Z. (2021). Quantum dots@porous carbon platform for the electrochemical sensing of oxytetracycline. Microchemical Journal, 167, 106341.

Zheng, J., Chen, X., Liu, Q., Zhong, G., & Zhuang, M. (2022). Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy. The Journal of cell biology, 221(1), e202103156.

Du, H., Li, Y., Zhou, N., Pu, C., Yin, J., Kong, X., Tian, H., & Jin, Y. (2021). Plasmonic Metal Oxide Nanocrystals via Surface Anchoring of Redox-Active Phosphorus Species. Chemistry of Materials.

Zhao, F., Zhang, C., Zhou, Q., Hang, K., Zou, X., Chen, Y., Wu, F., Rao, Q., Dai, A., Yin, W., Shen, D. D., Zhang, Y., Xia, T., Stevens, R. C., Xu, H. E., Yang, D., Zhao, L., & Wang, M. W. (2021). Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor. eLife, 10, e68719.

Zhu, C., Liu, W., Zhao, F., Chen, Y., Tao, H., He, Y. P., & Yang, X. (2021). Kinetic Resolution of 2,2-Disubstituted Dihydroquinolines through Chiral Phosphoric Acid-Catalyzed C6-Selective Asymmetric Halogenations. Organic letters, 23(11), 4104–4108.

Diao, M., & Huang, S. (2021). An Update on the Role of the Actin Cytoskeleton in Plasmodesmata: A Focus on Formins. Frontiers in plant science, 12, 647123.

Niu, M., Xu, S., Yang, J., Yao, D., Li, N., Yan, J., Zhong, G., & Song, G. (2021). Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs. The Journal of biological chemistry, 296, 100776.

Liu, L., Zhu, Z., Zhou, F., Xue, D., Hu, T., Luo, W., Qiu, Y., Wu, D., Zhao, F., Le, Z. & Tao, H. (2021). Catalytically Cleavable Detergent for Membrane Protein Studies. ACS Omega, 6(32), 21087—21093.

Guo, Z., Xie, J., Hu, T., Chen, Y., Tao, H., & Yang, X. (2021). Kinetic resolution of N-aryl β-amino alcohols via asymmetric aminations of anilines. Chemical Communications, 57(74), 9394–9397.

Larionova, M. D., Wu, L., Eremeeva, E. V., Natashin, P. V., Gulnov, D. V., Nemtseva, E. V., Liu, D., Liu, Z. J.,& Vysotski, E. S. (2022). Crystal structure of semisynthetic obelin-v. Protein science: a publication of the Protein Society, 31(2), 454–469.