科学研究

Liu, K., Wu, L., Yuan, S., Wu, M., Xu, Y., Sun, Q., Li, S., Zhao, S., Hua, T., and Liu, Z.J. (2020). Structural basis of CXC chemokine receptor 2 activation and signalling. Nature. 2020 Sep;585(7823):135-140.

Yu, J., Gimenez, L.E., Hernandez, C.C., Wu, Y., Wein, A.H., Han, G.W., McClary, K., Mittal, S.R., Burdsall, K., Stauch, B., Wu, L., Stevens, S.N., Peisley, A., Williams, S.Y., Chen, V., Millhauser, G.L., Zhao, S., Cone, R.D., and Stevens, R.C. (2020). Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding. Science 368, 428.

Lin, X., Li, M., Wang, N., Wu, Y., Luo, Z., Guo, S., Han, G.W., Li, S., Yue, Y., Wei, X., Xie, X., Chen, Y., Zhao, S., Wu, J., Lei, M., and Xu, F. (2020). Structural basis of ligand recognition and self-activation of orphan GPR52. Nature 579, 152-157.

Hua, T., Li, X., Wu, L., Iliopoulos-Tsoutsouvas, C., Wang, Y., Wu, M., Shen, L., Johnston, C.A., Nikas, S.P., Song, F., Song, X., Yuan, S., Sun, Q., Wu, Y., Jiang, S., Grim, T.W., Benchama, O., Stahl, E.L., Zvonok, N., Zhao, S., Bohn, L.M., Makriyannis, A., and Liu, Z.J. (2020). Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures. Cell 180, 655-665 e618.

Wang, J., Hua, T., and Liu, Z.J. (2020). Structural features of activated GPCR signaling complexes. Curr Opin Struct Biol 63, 82-89.

Tan, L., Zhou, Q., Yan, W., Sun, J., Kozikowski, A.P., Zhao, S., Huang, X.P., and Cheng, J. (2020). Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands. J Med Chem 63, 4579-4602.

Lou, R., Tang, P., Ding, K., Li, S., Tian, C., Li, Y., Zhao, S., Zhang, Y., and Shui, W. (2020). Hybrid Spectral Library Combining DIA-MS Data and a Targeted Virtual Library Substantially Deepens the Proteome Coverage. iScience 23, 100903.

Xia, L., Ma, Z., Tong, J., Tang, Y., Li, S., Qin, S., Lou, R., Zhao, S., Lei, X., and Shui, W. (2020). Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry. Anal Chim Acta 1102, 53-62.

Wu, F., Yang, L., Hang, K., Laursen, M., Wu, L., Han, G.W., Ren, Q., Roed, N.K., Lin, G., Hanson, M.A., Jiang, H., Wang, M.W., Reedtz-Runge, S., Song, G., and Stevens, R.C. (2020). Full-length human GLP-1 receptor structure without orthosteric ligands. Nat Commun 11, 1272.

Wang, J., Wu, M., Wu, L., Xu, Y., Li, F., Wu, Y., Popov, P., Wang, L., Bai, F., Zhao, S., Liu, Z.J., and Hua, T. (2020). The structural study of mutation-induced inactivation of human muscarinic receptor M4. IUCrJ 7, 294-305.

Zhang, B., Zhao, S., Yang, D., Wu, Y., Xin, Y., Cao, H., Huang, X.P., Cai, X., Sun, W., Ye, N., Xu, Y., Peng, Y., Zhao, S., Liu, Z.J., Zhong, G., Wang, M.W., and Shui, W. (2020). A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts. ACS Cent Sci 6, 213-225.

Li, X., Shen, L., Hua, T., & Liu, Z. J. (2020). Structural and Functional Insights into Cannabinoid Receptors. Trends Pharmacol. Sci., 41(9), 665-677.

Zhang J, Yan W, Duan W, Wüthrich K, and Cheng J.(2020) Tumor Immunotherapy Using A2A Adenosine Receptor Antagonists. Pharmaceuticals. 2020; 13(9):237.

Li, H., Yang, J., Tian, C., Diao, M., Wang, Q., Zhao, S., Li, S., Tan, F., Hua, T., Qin, Y., Lin, C., Deska-Gauthier, D., Thompson, G. J., Zhang, Y., Shui, W., Liu, Z. J., Wang, T. & Zhong, G. (2020). Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging. Nat Commun 11, 5699 (2020).

Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, and Hua T. (2020) Structural insights into the activation initiation of full-length mGlu1. Protein Cell. 2020 Dec 5.

Li, Shanshan,and Shui, Wenqing.(2020) Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques. Current Opinion in Biotechnology, 64, 24-31.    

Yan Lu, Shanshan Qin, Bingjie Zhang, Antao Dai, Xiaoqing Cai, Mengna Ma, Zhan-Guo Gao, Dehua Yang, Raymond C. Stevens, Kenneth A. Jacobson, Ming-Wei Wang, and Wenqing Shui.(2020) Correction to Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor. Analytical Chemistry 2020 92 (6), 4689-4689.

Mengna Ma, Shimeng Guo, Xi Lin, Shanshan Li, Yiran Wu, Yanping Zeng, Youhong Hu, Suwen Zhao, Fei Xu, Xin Xie, and Wenqing Shui.(2020) Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52. ACS Chemical Biology 2020 15 (12), 3275-3284.

Pu, J., Liu, Y., Zhang, J., An, B., Li, Y., Wang, X., Din, K., Qin, C., Li, K., Cui, M., Liu, S., Huang, Y., Wang, Y., Lv, Y., Huang, J., Cui, Z., Zhao, S., and Zhong, C. (2020). Virus Disinfection from Environmental Water Sources Using Living Engineered Biofilm Materials. Advanced Science.

Sanganahalli, B.G., Baker, K.L., Thompson, G.J., Herman, P., Shepherd, G.M., Verhagen, J.V., and Hyder, F. (2020). Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. Neuroimage 212, 116664.

Xu, L. , Tong, J. , Wu, Y. , Zhao, S. , & Lin, B. . (2020). Targeted Oxidation Strategy (TOS) for Potential Inhibition of Coronaviruses by Disulfiram — a 70-Year Old Anti- Alcoholism Drug.

Liu, C., Xia, L., Fu, K., Cao, X., Yan, W., Cheng, J., Roux, T., Peletier, L.A., Yin, X., and Guo, D. (2020). Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective. Eur J Pharmacol 880, 173157.

Tong, B., Wang, J., Cheng, Z., Liu, J., Wu, Y., Li, Y., Bai, C., Zhao, S., Yu, H., and Li, G. (2020). Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep. Genes (Basel) 11.

Zhang, B., Tastan, O.Y., Zhou, X., Guo, C.J., Liu, X., Thind, A., Hu, H.H., Zhao, S., and Liu, J.L. (2020). The proline synthesis enzyme P5CS forms cytoophidia in Drosophila. J Genet Genomics 47, 131-143.

Fan, L., Tan, L., Chen, Z., Qi, J., Nie, F., Luo, Z., Cheng, J., and Wang, S. (2020). Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands. Nat Commun 11, 1074.

Mao, Q., Zhang, B., Li, W., Tian, S., Shui, W., and Ye, N. (2020). Identification of Novel 1-O-Substituted Aporphine Analogues as Potent 5-HT2C Receptor Agonists. ACS Chem Neurosci 11, 549-559.

Chan, H.C.S., Xu, Y., Tan, L., Vogel, H., Cheng, J., Wu, D., and Yuan, S. (2020). Enhancing the Signaling of GPCRs via Orthosteric Ions. ACS Cent Sci 6, 274-282.

Sun, W., Huo, Y., Mei, Y., Zhou, Q., Zhao, S., and Zhuang, M. (2020). Identification of a Small Probe That Can Be Conjugated to Proteins by Proximity Labeling. ACS Chem Biol 15, 39-43.

Sun, H., Zhou, Y., Skaro, M.F., Wu, Y., Qu, Z., Mao, F., Zhao, S., and Xu, Y. (2020). Metabolic Reprogramming in Cancer Is Induced to Increase Proton Production. Cancer Res 80, 1143-1155.

Zhang, Y., Zhang, H., Wang, Z., Wu, Z., Wang, Y., Tang, N., Xu, X., Zhao, S., Chen, W., and Ji, Q. (2020). Programmable adenine deamination in bacteria using a Cas9-adenine-deaminase fusion. Chem Sci 11, 1657-1664.

Mei YY, Lee MH, Cheng TC, Hsiao IH, Wu DC, Zhou N.(2020) NMDA receptors sustain but do not initiate neuronal depolarization in spreading depolarization. Neurobiol Dis. 2020 Nov;145:105071.

Qiao, Y., Wang, Z., Tan, F., Chen, J., Lin, J., Yang, J., Li, H., Wang, X., Sali, A., Zhang, L., & Zhong, G. (2020). Enhancer Reprogramming Within Pre-existing Topologically Associated Domains Promotes TGF-β-Induced EMT and Cancer Metastasis. Molecular Therapy, 28(9).

Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW.(2020) A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Res. 2020 Dec;30(12):1098-1108.

Martin C, Gimenez LE, Williams SY, Jing Y, Wu Y, Hollanders C, Van der Poorten O, Gonzalez S, Van Holsbeeck K, Previti S, Lamouroux A, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S.(2020) Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure. J Med Chem. 2021 Jan 14;64(1):357-369.

White KL, Singla J, Loconte V, Chen JH, Ekman A, Sun L, Zhang X, Francis JP, Li A, Lin W, Tseng K, McDermott G, Alber F, Sali A, Larabell C, Stevens RC.(2020) Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography. Sci Adv. 2020 Dec 9;6(50):eabc8262.

Chen JJ, Herman P, Keilholz S, Thompson GJ.(2020) Editorial: Origins of the Resting-State fMRI Signal. Front Neurosci. 2020 Oct 27;14:594990.

Wang Y, Liu BX, Cheng JH, Su HN, Sun HM, Li CY, Yang L, Shen QT, Zhang YZ, Zhang X, Chen XL.(2020) Characterization of a New M4 Metalloprotease With Collagen-Swelling Ability From Marine Vibrio pomeroyi Strain 12613. Front Microbiol. 2020 Aug 7;11:1868.