科学研究

Song, G., Yang, D., Wang, Y., de Graaf, C., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z., Wang, M., and Stevens, R.C. (2017). Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature 546, 312-315.

Hua, T., Vemuri, K., Nikas, S.P., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Jiang, S., Ho, J., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., and Liu, Z. (2017). Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature 547, 468.

Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., and Xu, F. (2017). Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nature Communications 8, 15383.

Liu, D., Yuan, Y., Xu, R., and Cowburn, D. (2017). Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling. Protein & Cell 8, 67-71.

Zhou, Q., Sun, X., Xia, X., Fan, Z., Luo, Z., Zhao, S., Shakhnovich, E., and Liang, H. (2017). Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space. The Journal of Physical Chemistry Letters 8, 407-414.

Wu, F., Song, G., de Graaf, C., and Stevens, R.C. (2017). Structure and Function of Peptide-Binding G Protein-Coupled Receptors. Journal of Molecular Biology 429, 2726-2745.

Li, S., Cao, Q., Xiao, W., Guo, Y., Yang, Y., Duan, X., and Shui, W. (2017). Optimization of Acquisition and Data-Processing Parameters for Improved Proteomic Quantification by Sequential Window Acquisition of All Theoretical Fragment Ion Mass Spectrometry. Journal of Proteome Research 16, 738-747.

Ye, L., Ding, K., Zhao, F., Liu, X., Wu, Y., Liu, Y., Xue, D., Zhou, F., Zhang, X., Stevens, R.C., Xu, F., Zhao, S., and Tao, H. (2017). A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor. MedChemComm 8, 1332-1336.

Ma, J., Lu, Y., Wu, D., Peng, Y., Loa-Kum-Cheung, W., Peng, C., Quinn, R.J., Shui, W., and Liu, Z.-J. (2017). Ligand identification of the adenosine A2A receptor in self-assembled nanodiscs by affinity mass spectrometry. Analytical Methods 9, 5851-5858.

Hou, Y., Hu, W., Li, X., Skinner, J.J., Liu, D., and Wüthrich, K. (2017). Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by 19F-NMR observation of 4-fluorophenylalanine. Journal of Biomolecular NMR 68, 1-6.

Liu, D., and Cowburn, D. (2017). Segmental Isotopic Labeling of Proteins for NMR Study Using Intein Technology. In Split Inteins: Methods and Protocols, H.D. Mootz, ed. (New York, NY: Springer New York), pp. 131-145.

Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., De Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T.D., Sierra, R.G., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P.R., Lau, J., Chrezov, V., Yang, H., Hanson, M.A., Stevens, R.C., Zhao, Q., Jiang, H., Wang, M., and Wu, B. (2017). Structure of the full-length glucagon class B G-protein-coupled receptor. Nature 546, 259.

Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., and Xu, H.E. (2017). Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell 170, 457-469.

de Graaf, C., Song, G., Cao, C., Zhao, Q., Wang, M.-W., Wu, B., and Stevens, R.C. (2017). Extending the Structural View of Class B GPCRs. Trends in Biochemical Sciences 42, 946-960.

An, B., Wang, X., Cui, M., Gui, X., Mao, X., Liu, Y., Li, K., Chu, C., Pu, J., Ren, S., Wang, Y., Zhong, G., Lu, T.K., Liu, C., and Zhong, C. (2017). Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains. ACS Nano 11, 6985-6995.

Li, Z., Tang, Y., Wu, Y., Zhao, S., Bao, J., Luo, Y., and Li, D. (2017). Structural insights into the committed step of bacterial phospholipid biosynthesis. Nature Communications 8, 1691.

Wang, X.-j., Qiao, Y., Xiao, M.M., Wang, L., Chen, J., Lv, W., Xu, L., Li, Y., Wang, Y., Tan, M.-d., Huang, C., Li, J., Zhao, T.C., Hou, Z., Jing, N., and Chin, Y.E. (2017). Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. Cell Reports 18, 933-946.

Jiang, Y., Zhu, Y., Liu, Z.-J., and Ouyang, S. (2017). The emerging roles of the DDX41 protein in immunity and diseases. Protein & Cell 8, 83-89.

Wang, X., Li, S., Wang, H., Shui, W., and Hu, J. (2017). Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae. eLife 6, e23816.

Zhang, W., Cui, T., Yang, L., Zhang, C., Cai, M., Sun, S., Yao, Y., Zhuang, X., and Zhang, F. (2017). Hollow-structured conjugated porous polymer derived Iron/Nitrogen-codoped hierarchical porous carbons as highly efficient electrocatalysts. Journal of Colloid and Interface Science 497, 108-116.

Li, Z., Li, Y., Chen, W., Cao, Q., Guo, Y., Wan, N., Jiang, X., Tang, Y.J., Wang, Q., and Shui, W. (2017). Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis. Analytical Chemistry 89, 877-885.

Ma, Y., Yue, Y., Ma, Y., Zhang, Q., Zhou, Q., Song, Y., Shen, Y., Li, X., Ma, X., Li, C., Hanson, M.A., Han, G.W., Sickmier, E.A., Swaminath, G., Zhao, S., Stevens, R.C., Hu, L.A., Zhong, W., Zhang, M., and Xu, F. (2017). Structural Basis for Apelin Control of the Human Apelin Receptor. Structure 25, 858.

Pan, G., Gao, X., Fan, K., Liu, J., Meng, B., Gao, J., Wang, B., Zhang, C., Han, H., Ai, G., Chen, Y., Wu, D., Liu, Z.-J., and Yang, K. (2017). Structure and Function of a C–C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis. ACS Chemical Biology 12, 142-152.

Gessner, C., Steinchen, W., Bédard, S., J. Skinner, J., Woods, V.L., Walsh, T.J., Bange, G., and Pantazatos, D.P. (2017). Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution. Scientific Reports 7, 3789.

Yang, L.-y., Liu, X.-f., Yang, Y., Yang, L.-l., Liu, K.-w., Tang, Y.-b., Zhang, M., Tan, M.-j., Cheng, S.-m., Xu, Y.-c., Yang, H.-y., Liu, Z.-j., Song, G.-j., and Huang, W. (2017). Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities. Acta Pharmacologica Sinica 38, 56-68.

Yang, L., Tae, H.-S., Fan, Z., Shao, X., Xu, S., Zhao, S., Adams, D.J., and Wang, C. (2017). A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA. In Mar Drugs.

Vos De Wael, R., Hyder, F., and Thompson, G.J. (2017). Effects of Tissue-Specific Functional Magnetic Resonance Imaging Signal Regression on Resting-State Functional Connectivity. Brain Connectivity 7, 482 - 490.

汪志华, 孟萌萌, 曹海杰, 白雯雯, and 水雯箐 (2017). 药物靶标配体高通量筛选的亲和质谱技术研究. 生命的化学 37, 113-120.