科学研究

Yang, S., Wu, Y., Xu, T.-H., de Waal, P.W., He, Y., Pu, M., Chen, Y., DeBruine, Z.J., Zhang, B., Zaidi, S.A., Popov, P., Guo, Y., Han, G.W., Lu, Y., Suino-Powell, K., Dong, S., Harikumar, K.G., Miller, L.J., Katritch, V., Xu, H.E., Shui, W., Stevens, R.C., Melcher, K., Zhao, S., and Xu, F. (2018). Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature 560, 666-670.

Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L.F., Huang, X., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., and Liu, Z. (2018). 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell 172, 719-730.

Zhang, X., Dong, S., and Xu, F. (2018). Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors. Trends in Biochemical Sciences 43, 1033-1046.

Qin, S., Meng, M., Yang, D., Bai, W., Lu, Y., Peng, Y., Song, G., Wu, Y., Zhou, Q., Zhao, S., Huang, X., McCorvy, J.D., Cai, X., Dai, A., Roth, B.L., Hanson, M.A., Liu, Z., Wang, M., Stevens, R.C., and Shui, W. (2018). High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. Chemical Science 9, 3192-3199.

Tan, L., Yan, W., McCorvy, J.D., and Cheng, J. (2018). Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure–Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. Journal of Medicinal Chemistry 61, 9841-9878.

Thompson, G.J. (2018). Neural and metabolic basis of dynamic resting state fMRI. NeuroImage 180, 448-462.

Zhou, J., Zhao, S., and Dunker, A.K. (2018). Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation. Journal of Molecular Biology 430, 2342-2359.

Liu, X., Gao, Z.-G., Wu, Y., Stevens, R.C., Jacobson, K.A., and Zhao, S. (2018). Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Scientific Reports 8, 8084.

Xiao, W., Duan, X., Lin, Y., Cao, Q., Li, S., Guo, Y., Gan, Y., Qi, X., Zhou, Y., Guo, L., Qin, P., Wang, Q., and Shui, W. (2018). Distinct Proteome Remodeling of Industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock. Journal of Proteome Research 17, 1812-1825.

Cheng, X.-F., Wang, R., and Shen, Q.-T. (2018). Cryo-ET bridges the gap between cell biology and structural biophysics. Chinese Physics B 27, 066803.

Yang, Z., Han, S., Keller, M., Kaiser, A., Bender, B.J., Bosse, M., Burkert, K., Koegler, L.M., Wifling, D., Bernhardt, G., Plank, N., Littmann, T., Schmidt, P., Yi, C., Li, B., Ye, S., Zhang, R., Xu, B., Larhammar, D., Stevens, R.C., Huster, D., Meiler, J., Zhao, Q., Beck-Sickinger, A.G., Buschauer, A., and Wu, B. (2018). Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor. Nature 556, 520.

Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K.S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O.P., Hanson, M.A., Stevens, R.C., Wang, M., Reedtz-Runge, S., Jiang, H., Zhao, Q., and Wu, B. (2018). Structure of the glucagon receptor in complex with a glucagon analogue. Nature 553, 106.

Qiu, B., Xia, B., Zhou, Q., Lu, Y., He, M., Hasegawa, K., Ma, Z., Zhang, F., Gu, L., Mao, Q., Wang, F., Zhao, S., Gao, Z., and Liao, J. (2018). Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate. Cell Research 28, 644-654.

Wang, Y.S., Zhang, B., Zhu, J., Yang, C.L., Guo, Y., Liu, C.L., Liu, F., Huang, H., Zhao, S., Liang, Y., Jiao, R.H., Tan, R.X., and Ge, H.M. (2018). Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. Journal of the American Chemical Society 140, 10909-10914.

Cao, C., Tan, Q., Xu, C., He, L., Yang, L., Zhou, Y., Zhou, Y., Qiao, A., Lu, M., Yi, C., Han, G.W., Wang, X., Li, X., Yang, H., Rao, Z., Jiang, H., Zhao, Y., Liu, J., Stevens, R.C., Zhao, Q., Zhang, X.C., and Wu, B. (2018). Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nature Structural & Molecular Biology 25, 488-495.

Liu, D., Wei, Y., Liu, X., Zhou, Y., Jiang, L., Yin, J., Wang, F., Hu, Y., Nanjaraj Urs, A.N., Liu, Y., Ang, E.L., Zhao, S., Zhao, H., and Zhang, Y. (2018). Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole. Nature Communications 9, 4224.

Vass, M., Kooistra, A.J., Yang, D., Stevens, R.C., Wang, M.-W., and de Graaf, C. (2018). Chemical Diversity in the G Protein-Coupled Receptor Superfamily. Trends in Pharmacological Sciences 39, 494-512.

Qiang, M., Dong, X., Zha, Z., Zuo, X.-K., Song, X.-L., Zhao, L., Yuan, C., Huang, C., Tao, P., Hu, Q., Li, W.-G., Hu, W., Li, J., Nie, Y., Buratto, D., Zonta, F., Ma, P., Yu, Z., Liu, L., Zhang, Y., Yang, B., Xie, J., Xu, T.-L., Qu, Z., Yang, G., and Lerner, R.A. (2018). Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death. Proceedings of the National Academy of Sciences 115, E7469.

Shang, W., Jiang, Y., Boettcher, M., Ding, K., Mollenauer, M., Liu, Z., Wen, X., Liu, C., Hao, P., Zhao, S., McManus, M.T., Wei, L., Weiss, A., and Wang, H. (2018). Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. Proceedings of the National Academy of Sciences 115, E4051.

Chan, H.C.S., Wang, J., Palczewski, K., Filipek, S., Vogel, H., Liu, Z.-J., and Yuan, S. (2018). Exploring a new ligand binding site of G protein-coupled receptors. Chemical Science 9, 6480-6489.

Zhao, H., Tian, X., He, L., Li, Y., Pu, W., Liu, Q., Tang, J., Wu, J., Cheng, X., Liu, Y., Zhou, Q., Tan, Z., Bai, F., Xu, F., Smart, N., and Zhou, B. (2018). Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target. Cell Reports 25, 1241-1254.e1245.

Pu, M., Xu, Z., Peng, Y., Hou, Y., Liu, D., Wang, Y., Liu, H., Song, G., and Liu, Z.-J. (2018). Protein crystal quality oriented disulfide bond engineering. Protein & Cell 9, 659-663.

Popov, P., Peng, Y., Shen, L., Stevens, R.C., Cherezov, V., Liu, Z.-J., and Katritch, V. (2018). Computational design of thermostabilizing point mutations for G protein-coupled receptors. eLife 7, e34729.

Zhang, W., Sun, S., Yang, L., Lu, C., He, Y., Zhang, C., Cai, M., Yao, Y., Zhang, F., and Zhuang, X. (2018). Polymer nanosheets derived porous carbon nanosheets as high efficient electrocatalysts for oxygen reduction reaction. Journal of Colloid and Interface Science 516, 9-15.

Huang, L., Tong, X., Wang, F., Luo, L., Jin, R., Fu, Y., Zhou, G., Li, D., Song, G., Liu, Y., and Zhu, F. (2018). Novel mutations in PATL2 cause female infertility with oocyte germinal vesicle arrest. Human Reproduction 33, 1183-1190.

Li, Z., Lu, Y., Guo, Y., Cao, H., Wang, Q., and Shui, W. (2018). Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection. Analytica Chimica Acta 1029, 50-57.

Zhang, S., Ding, K., Shen, Q.-J., Zhao, S., and Liu, J.-L. (2018). Filamentation of asparagine synthetase in Saccharomyces cerevisiae. PLOS Genetics 14, e1007737.

Johnson, F.K., Delpech, J.-C., Thompson, G.J., Wei, L., Hao, J., Herman, P., Hyder, F., and Kaffman, A. (2018). Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Translational Psychiatry 8, 49.

Qu, L., Jiang, Y., Cheng, C., Wu, D., Meng, B., Chen, Z., Zhu, Y., Shaw, N., Ouyang, S., and Liu, Z.-J. (2018). Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins. Structure 26, 1259-1265.e1253.

Ye, M., Yang, J., Tian, C., Zhu, Q., Yin, L., Jiang, S., Yang, M., and Shu, Y. (2018). Differential roles of NaV1.2 and NaV1.6 in regulating neuronal excitability at febrile temperature and distinct contributions to febrile seizures. Scientific Reports 8, 753.

Billings, J.C.W., Thompson, G.J., Pan, W.-J., Magnuson, M.E., Medda, A., and Keilholz, S. (2018). Disentangling Multispectral Functional Connectivity With Wavelets. Frontiers in Neuroscience 12.

Zhao, M., Cheng, J., Guo, B., Duan, J., and Che, C.-T. (2018). Momilactone and Related Diterpenoids as Potential Agricultural Chemicals. Journal of Agricultural and Food Chemistry 66, 7859-7872.

Miao, C., Yang, Y., Li, S., Guo, Y., Shui, W., and Cao, Q. (2018). Discrimination and quantification of homologous keratins from goat and sheep with dual protease digestion and PRM assays. Journal of Proteomics 186, 38-46.

Qiu, X., Huang, Y., Wu, D., Mao, F., Zhu, J., Yan, W., Luo, H.-B., and Li, J. (2018). Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation. Bioorganic & Medicinal Chemistry 26, 119-133.

Peng, Y., Zhao, S., Wu, Y., Cao, H., Xu, Y., Liu, X., Shui, W., Cheng, J., Zhao, S., Shen, L., Ma, J., Quinn, R.J., Stevens, R.C., Zhong, G., and Liu, Z.-J. (2018). Identification of natural products as novel ligands for the human 5-HT2C receptor. Biophysics Reports 4, 50-61.