- Wenqing Shui
- PI, Research Associate Professor
- Research Focus：BIO-MS AND OMICS TECHNOLOGY
- Email：shuiwq@@shanghaitech.edu.cn
- Office：Room B104, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai, China
- Lab Page：shuilab.ihuman.shanghaitech.edu.cn
The limitations of most commonly used techniques for GPCRligand screening and proteomics research highlights the needsfor more sensitive, efficient and robust technologies that cansubstantially facilitate GPCR drug discovery and cell signalingstudy. The Shui Wen-Qing group is dedicated to developingversatile mass spectrometry (MS)-based methods which areintegrated with biochemical, cell biology and structural biologyapproaches for GPCR research in three specific directions:
I. High-throughput identification of functionalmodulators of GPCR targets with the affinity massspectrometry technique. New GPCR ligands identi edin our study will serve as critical chemical tools forelucidating GPCR signaling mechanism or potentialleads for downstream drug development.
II. Discovery of disease-related biomarkers orpotential drug targets from GPCR superfamily withcutting-edge proteomics techniques. Our technicalinnovation will accelerate the identification of newGPCR targets involved in brain disease progressionand shed light on the structural basis of GPCRmodulation and biased signaling.
III. Informatics tool development for ef cient miningof proteomics and metabolomics datasets tosupport GPCR ligand screening and GPCR targetedproteomics.