Functional connectivity of neuronal networks is fundamentally important for information processing of the brain. My research group studies how animal cognition and behaviors are mediated by local neural networks and how these functions are disrupted by neurological and mental disorders at the cellular and network level. Using techniques of in vivo two-photon fluorescence microscopy, miniature endoscope imaging in freely moving animals, and patch clamp recordings approaches, our group investigate mechanisms for how population activity of neuronal ensembles code perception and memory that are associated with animals’ behaviors, how alterations in the local neuronal network are related to brain diseases, and how ensemble activity is modulated by GPCRs. Unveiling the neuron population coding in brain diseases and the role of GPCRs in it will provide critical insight into development of new therapeutic avenues.