我们的研究团队致力于深入探讨听觉神经机制，特别关注耳蜗中不同类型细胞的发育和形成过程，以及毛细胞再生的机制。我们致力于开发和优化新型腺相关病毒（AAV），并探索其在治疗耳聋、遗传性视觉疾病以及神经系统疾病中的应用。通过与医院的紧密合作，我们深入研究疾病的发病机制，并探索可能的治疗方法。这样的跨学科合作不仅加深了我们对听觉问题的理解，也为未来开发更为有效的基因治疗提供了关键的信息和基础。

• 1. Simeng Zhao*^#; Qiuxiang Yang*; Zehua Yu*; Cenfeng Chu; Shengqi Dai; Hongli Li; Min Diao; Lingyue Feng; Junzi Ke; Yilin Xue; Qifang Zhou; Yan Liu; Hanhui Ma; Chao-Po Lin; Yong-Gang Yao; Guisheng Zhong^#.Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness.NEURON. 21 Apr 2025. 113(10).

• 2. Zhao, Simeng*; Ke, Junzi; Yang, Boyu; Tan, Fangzhi; Yang, Jie; Lin, Chao Po; Wang, Haopeng^#; Zhong, Guisheng^#.A protective AAV vaccine for SARS-CoV-2.SIGNAL TRANSDUCTION AND TARGETED THERAPY. 05 Sep 2022. 7(1).

  
  

• 3. Li, Hui*; Yang, Jie; Tian, Cuiping; Diao, Min; Wang, Quan; Zhao, Simeng; Li, Shanshan; Tan, Fangzhi; Hua, Tian; Qin, Ya; Lin, Chao-Po; Deska-Gauthier, Dylan; Thompson, Garth J.; Zhang, Ying; Shui, Wenqing; Liu, Zhi-Jie; Wang, Tong; Zhong, Guisheng^#.Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.NATURE COMMUNICATIONS. 2020. 11(1):5699.

  
  

• 4. Tan, Fangzhi*^#; Chu, Cenfeng*; Qi, Jieyu*; Li, Wenyan*; You, Dan; Li, Ke; Chen, Xin; Zhao, Weidong; Cheng, Cheng; Liu, Xiaoyi; Qiao, Yunbo; Su, Bing; He, Shuijin; Zhong, Chao; Li, Huawei^#; Chai, Renjie^#; Zhong, Guisheng^#.AAV-ie enables safe and efficient gene transfer to inner ear cells.NATURE COMMUNICATIONS. 19 Aug 2019. 10.

  
  

• 5. Liu, Yan*; Qi, Jieyu*; Chen, Xin*; Tang, Mingliang*; Chu, Cenfeng; Zhu, Weijie; Li, Hui; Tian, Cuiping; Yang, Guang; Zhong, Chao; Zhang, Ying; Ni, Guangjian; He, Shuijin^#; Chai, Renjie^#; Zhong, Guisheng^#.Critical role of spectrin in hearing development and deafness.SCIENCE ADVANCES. Apr 2019. 5(4).