建立结构生物学整合研究平台，解码孤儿受体自激活与GPCR新型调控机制，助力从靶点结构到药物发现的闭环研究。

1.       Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W*, Wang S*, Xu HE*, Xu F*. “Recognition of methamphetamine and other amines by trace amine receptor TAAR1”. Nature. 2023 Dec;624(7992):663-671. 

2.       Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J*, Lei M*, Xu F*. “Structural basis of ligand recognition and self-activation of orphan GPR52”. Nature. 2020 Mar;579(7797):152-157.

3.       Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F*. “Crystal structure of the Frizzled 4 receptor in a ligand-free state”. Nature. 2018 Aug;560(7720):666-670. 

4.       Lin X*, Wei X, Pu N, Wang L, Zhang Z, Li C, Yue Y, Liu J, Tan Q, Sun Q, Xu F*. “Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode”. Cell Res. 2025 Aug 15. doi: 10.1038/s41422-025-01165-w. 

5.       Yue Y, Xu C, Wu L, Na M, Xu K, Chen X, Song Y, Weng S, Xu L, Li F, Lin X, Wang A, Liu J, Xu F. Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex. Nat Commun. 2025 Aug;16:7403.

6.       Yue Y, Liu L, Wu L, Xu C, Na M, Liu S, Liu Y, Li F, Liu J, Shi S, Lei H, Zhao M, Yang T, Ji W, Wang A, Hanson MA, Stevens RC, Liu J, Xu F. Structural insights into the regulation of monomeric and dimeric apelin receptor. Nat Commun. 2025 Jan;16(1):310.

7.       Liu H, Yan P, Zhang Z, Han H, Zhou Q, Zheng J, Zhang J, Xu F*, Shui W*. Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor. J Am Chem Soc. 2024 Jul; doi: 10.1021/jacs.4c03922.

8.       Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S*, Xu F*. The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell Rep. 2024 Jul;43(7):114505.

9.       Zhang Z, Zheng Y, Xu L, Yue Y, Xu K, Li F, Xu F*. Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15. Cell Discov. 2024 Jun;10(1):69.

10.    Yan P, Lin X, Wu L, Xu L, Li F, Liu J, Xu F*. The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer. Nat Commun. 2024 Jun;15(1):5255. doi: 10.1038/s41467-024-49625-y.

11.    Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F*. “Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8”. Science Advances. 2024 Feb; 10:eadj7500.

12.    Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X*, Xu F*. “A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways”. Cell Discov. 2024 Jan;10(1):3.  

13.    Li C, Wu Y, Wang W, Xu L, Zhou Y, Yue Y, Wu T, Yang M, Qiu Y, Huang M, Zhou F, Zhou Y, Hao P, Lin Z, Wang MW, Zhao S, Yang D, Xu F*, Tao H*. “Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7”. J Med Chem. 2023 Sep 14;66(17):11855-11868. (co-corresponding)

14.    Chen Y, Chen B, Wu T, Zhou F, Xu F*. “Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A”. Protein Cell. 2023 Jun 7;14(6):464-468. 

15.    Fan Y, Lin X, Pan B, Chen B, Liu D, Wüthrich K*, Xu F*. “Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by (19)F-NMR and cryo-electron microscopy”. MedComm. 2023 Apr;4(2):e260. 

16.    Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F*. “The activation mechanism and antibody binding mode for orphan GPR20”. Cell Discov. 2023 Feb 28;9(1):23. 

17.    Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J*, Zhao S*, Xu F*. “Cryo-EM structures of orphan GPR21 signaling complexes”. Nat Commun. 2023 Jan 13;14(1):216.  

18.    Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault É, Longpré JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F*. “Structural insight into apelin receptor-G protein stoichiometry”. Nat Struct Mol Biol. 2022 Jul;29(7):688-697.

19.    Zheng Y, Liu H, Chen Y, Dong S, Wang F, Wang S, Li GL, Shu Y*, Xu F*. “Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel”. Neuron. 2022 Jan 19;110(2):237-247.

20.    Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G*, Xu F*. “Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G(s)”. Cell Res. 2021 Dec;31(12):1311-1314. 

21.    Zhang X, Dong S, Xu F*. “Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors”. Trends Biochem Sci. 2018 Dec;43(12):1033-1046. Review. 

22.    Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F*. “Structural Basis for Apelin Control of the Human Apelin Receptor”. Structure. 2017 Jun 6;25(6):858-866. 

23.    Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W*, Tao H*, Xu F*. “Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand”. Nat Commun. 2017 May 17;8:15383. 

24.    Zhang X, Stevens RC, Xu F*. “The importance of ligands for G protein-coupled receptor stability”. Trends Biochem Sci. 2015 Feb;40(2):79-87. Review.