徐菲 副教授 研究员 博士生导师
学位:博士 所在院所:iHuman研究所 职务:助理所长 荣誉称号: 最终学历: 毕业院校:美国斯克利普斯研究所 联系电话:021-20685015 传真: 办公室:人字楼A203 通讯地址: 电子邮箱:xufei@shanghaitech.edu.cn 课题组名称: 课题组网站: 研究方向:膜蛋白结构药理学

教育经历

  • 2002.9—2006.7,中国科学技术大学,学士
  • 2006.7—2011.6,The Scripps Research Institute,博士

博士后及工作经历

  • 2011.7——2013.9,RuiYi Inc.,科学顾问与研发总监

研究内容

课题组使用世界领先的膜蛋白结构生物学与生物化学、细胞生物学、药理学结合的方法,研究与人类胚胎发育及疾病发生密切

相关的一类信号转导受体-GPCR靶点,包括其蛋白结构,信号转导复合物结构与功能,以及药物小分子与抗体的筛选和验证等。


研究成果展示


代表性论文

(1): Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault É, Longpré JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F. Structural insight into apelin receptor-G protein stoichiometry. Nat Struct Mol Biol. 2022 Jul;29(7):688-697. doi: 10.1038/s41594-022-00797-5. Epub 2022 Jul 11. PMID: 35817871. (IF: 15.4)

(2): Zheng Y, Liu H, Chen Y, Dong S, Wang F, Wang S, Li GL, Shu Y, Xu F. Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron. 2022 Jan 19;110(2):237-247.e4. doi: 10.1016/j.neuron.2021.10.029. (IF: 17.2)

(3): Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F. Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Cell Res. 2021 Dec;31(12):1311-1314. doi: 10.1038/s41422-021-00525-6. (IF: 46.3)

(4): Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F. Structural basis of ligand recognition and self-activation of orphan GPR52. Nature. 2020 Mar;579(7797):152-157. doi: 10.1038/s41586-020-2019-0. (IF: 69.5)

(5): Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. (IF: 69.5)

(6): Zhang X, Dong S, Xu F. Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors. Trends Biochem Sci. 2018 Dec;43(12):1033-1046. doi: 10.1016/j.tibs.2018.09.002. Review (IF: 14.3)

(7): Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun. 2017 May 17;8:15383. doi: 10.1038/ncomms15383. (IF: 17.7)

(8): Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F. Structural Basis for Apelin Control of the Human Apelin Receptor. Structure. 2017 Jun 6;25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. (IF: 5.0)

(9): Zhang X, Stevens RC, Xu F. The importance of ligands for G protein-coupled receptor stability. Trends Biochem Sci. 2015 Feb;40(2):79-87. doi: 10.1016/j.tibs.2014.12.005. Review (IF: 14.3)

(10): Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC. Structure of an agonist-bound human A2A adenosine receptor. Science. 2011 Apr 15;332(6027):322-7. doi: 10.1126/science.1202793. (IF: 63.7)


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课题组成员

课题组合影


工作内容