主要研究内容为开发和应用整合建模来用于生物大分子以及全细胞建模，详情请见课题组网站：https://compbio.ihuman.shanghaitech.edu.cn/

9. S. Yuan*, L. Xia*, C. Wang*, F. Wu , B. Zhang, C. Pan, X. Lei, R.C. Stevens, A. Sali, L. Sun #, W. Shui #. Conformational dynamics of the activated GLP-1 receptor-Gs complex revealed by cross-linking mass spectrometry and integrative structure modeling. ACS central science, 9(5), 992-100, 2023.

8. K. Zhang*, C. Wang, L. Sun, J. Zheng#, Prediction of Gene Co-expression from Chromatin Contacts with Graph Attention Network, Bioinformatics, 38(19), 4457-4465, 2022.

7. X. Zhong*, J. Zhao, L. Sun#. Integrative modelling of the cell, Acta Biochim Biophys Sin, 54(9):1213-1221, 2022. 

6. A. Li*, S. Zhang, V. Loconte, Y. Liu, A. Ekman, G.J. Thompson, A. Sali, R.C. Stevens, K. White#, J. Singla#, L. Sun#. An Intensity-based Post-processing Tool for 3D Instance Segmentation of Organelles in Soft X-ray Tomograms. PLoS One, 17(9), e0269887, 2022.

5. A. Li*, X. Zhang*, J. Singla, K. White, V. Loconte, C. Hu, C. Zhang, S. Li, W. Li, J.P. Francis, C. Wang, A. Sali, L. Sun#, X. He#, R.C. Stevens#. Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion. PLoS One, 17, e0265567, 2022.

4. B. Raveh*, L. Sun*, K.L. White*, T. Sanyal*, J. Tempkin, D. Zheng, K.B. Pilla, J. Singla, C. Wang, J. Zhao, A. Li, N.A. Graham, C. Kesselman, R.C. Stevens, A. Sali#. Bayesian metamodeling of complex biological systems across varying representations. Proc Natl Acad Sci USA,118, e2104559118, 2021.

3. K. White*, J. Singla, V. Loconte, J.H. Chen, A. Ekman, L. Sun, X. Zhang, J.P. Francis, A. Li, W. Lin, K. Tseng, G. McDermott, A. Frank, A. Sali#, C. Larabell#, R.C. Stevens#. Visualizing subcellular rearrangements in intact β-cells using soft X-ray tomography. Sci Adv, 6(50), eabc8262, 2020.

2. L. Portilla*, J. Zhao#, W. Yan, L. Sun, F. Li, M. Robin, M. Wei, Z. Cui, L.G. Occhipinti#, T.D. Anthopoulos#, V. Pecunia#. Ambipolar deep-subthreshold printed-carbon-nanotube transistors for ultralow-voltage and ultralow-power electronics. ACS nano, 14(10), 14036-14046, 2020.

1. M. Wu*, L. Sun, Q. Zhou, Y. Peng, Z. Liu, S. Zhao#. Molecular mechanism of acetate transport through the acetate channel SatP. J Chem Inf Model, 59(5), 2374-2382, 2019.

9. S. Yuan*, L. Xia*, C. Wang*, F. Wu , B. Zhang, C. Pan, X. Lei, R.C. Stevens, A. Sali, L. Sun #, W. Shui #. Conformational dynamics of the activated GLP-1 receptor-Gs complex revealed by cross-linking mass spectrometry and integrative structure modeling. ACS central science, 9(5), 992-100, 2023.

8. K. Zhang*, C. Wang, L. Sun, J. Zheng#, Prediction of Gene Co-expression from Chromatin Contacts with Graph Attention Network, Bioinformatics, 38(19), 4457-4465, 2022.

7. X. Zhong*, J. Zhao, L. Sun#. Integrative modelling of the cell, Acta Biochim Biophys Sin, 54(9):1213-1221, 2022. 

6. A. Li*, S. Zhang, V. Loconte, Y. Liu, A. Ekman, G.J. Thompson, A. Sali, R.C. Stevens, K. White#, J. Singla#, L. Sun#. An Intensity-based Post-processing Tool for 3D Instance Segmentation of Organelles in Soft X-ray Tomograms. PLoS One, 17(9), e0269887, 2022.

5. A. Li*, X. Zhang*, J. Singla, K. White, V. Loconte, C. Hu, C. Zhang, S. Li, W. Li, J.P. Francis, C. Wang, A. Sali, L. Sun#, X. He#, R.C. Stevens#. Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion. PLoS One, 17, e0265567, 2022.

4. B. Raveh*, L. Sun*, K.L. White*, T. Sanyal*, J. Tempkin, D. Zheng, K.B. Pilla, J. Singla, C. Wang, J. Zhao, A. Li, N.A. Graham, C. Kesselman, R.C. Stevens, A. Sali#. Bayesian metamodeling of complex biological systems across varying representations. Proc Natl Acad Sci USA,118, e2104559118, 2021.

3. K. White*, J. Singla, V. Loconte, J.H. Chen, A. Ekman, L. Sun, X. Zhang, J.P. Francis, A. Li, W. Lin, K. Tseng, G. McDermott, A. Frank, A. Sali#, C. Larabell#, R.C. Stevens#. Visualizing subcellular rearrangements in intact β-cells using soft X-ray tomography. Sci Adv, 6(50), eabc8262, 2020.

2. L. Portilla*, J. Zhao#, W. Yan, L. Sun, F. Li, M. Robin, M. Wei, Z. Cui, L.G. Occhipinti#, T.D. Anthopoulos#, V. Pecunia#. Ambipolar deep-subthreshold printed-carbon-nanotube transistors for ultralow-voltage and ultralow-power electronics. ACS nano, 14(10), 14036-14046, 2020.

1. M. Wu*, L. Sun, Q. Zhou, Y. Peng, Z. Liu, S. Zhao#. Molecular mechanism of acetate transport through the acetate channel SatP. J Chem Inf Model, 59(5), 2374-2382, 2019.