刘志杰 教授 研究员 博士生导师
学位: 所在院所:iHuman研究所、生命科学与技术学院 职务:iHuman执行所长 荣誉称号: 最终学历: 毕业院校: 联系电话: 传真: 办公室: 通讯地址: 电子邮箱:liuzhj@shanghaitech.edu.cn 课题组名称: 课题组网站: 研究方向:结构生物学,药物设计

教育经历

  • 1980/04—1984/07,天津师范大学,学士
  • 1984/09—1987/07,天津师范大学,硕士
  • 1991/09—1995/01,中国科学院生物物理研究所,博士研究生

博士后及工作经历

  • 1987/09——1991/08,天津师范大学,讲师
  • 1995/01——1995/04,美国匹兹堡大学,博士后
  • 1995/05——1997/10,美国佐治亚大学,博士后
  • 1997/11——2002/07,美国佐治亚大学,助理研究员
  • 2002/08——2006/10,美国佐治亚大学,副研究员
  • 2006/11——2013/04,中国科学院生物物理研究所,研究员
  • 2013/05——2017/04,上海科技大学生命科学与技术学院/iHuman 研究所,正教授(TENURE-TRACK)
  • 2017/05——至今,上海科技大学生命科学与技术学院/iHuman 研究所,正教授(TENURED

研究内容

以结构生物学及生物成像方法研究细胞信号转导的分子机制。目前聚焦与精神类疾病、代谢类疾病和肿瘤与免疫类疾病相关G蛋白偶联受体的结构与功能研究及相关靶点的药物设计。

研究成果展示

2022年首次破解人源苦味受体的结构与功能机制,研究成果发表于《Science》;

2020年:人源大麻素受体 CB2及CB2分别与激动剂及下游信号G蛋白复合物的冷冻电镜结构与功能研究成果于《Cell》

2020年:与癌症治疗相关的人源趋化因子受体CXCR2与白介素IL8及G蛋白复合物研究成果发表于《Nature》;

2019年:人源大麻素受体 CB2与拮抗剂复合物的结构与功能研究发表于《Cell》

2018年:为探索 GPCR 药物的多重药理学特性,解析了五羟色胺 2C 受体分别与激动剂及拮抗剂复合物的晶体结构 。揭示了两种配体获得多重药理学特性及选择性的结构基础。成果发表于 《Cell》

2017年:人源大麻素受体 CB1分别与激动剂AM841及AM1542复合物的结构与功能研究发表于《Nature》。与Stevens课题组合作解析了与糖尿病相关的胰高血糖素样肽受体GLP1R 的晶体结构并发表于《Nature》

2016年:人源大麻素受体 CB1与拮抗剂AM6538复合物的结构与功能研究发表在《Cell》上,入选《Cell》十佳论文和上海市十大科技事件.

研究生获奖情况:

2017年:华甜获中科院院长特别奖,中科院优秀博士学位论文奖,三次获研究生国家奖学金

2019年:李潇婷获教育部博新计划及上海市超博计划支持

2020年:刘凯雯获中科院优秀博士学位论文奖,教育部博新计划及上海市超博计划支持

2021年:张进一获研究生国家奖学金

2022年:周雅丽获上海市优秀毕业生


代表性论文

1. Liu, Kaiwen*; Wu, Lijie; Yuan, Shuguang; Wu, Meng; Xu, Yueming; Sun, Qianqian; Li, Shu; Zhao, Suwen; Hua, Tian#; Liu, Zhi-Jie#.Structural basis of CXC chemokine receptor 2 activation and signalling.NATURE. Jul 2020.

2. Li, Xiaoting*; Hua, Tian; Vemuri, Kiran; Ho, Jo-Hao; Wu, Yiran; Wu, Lijie; Popov, Petr; Benchama, Othman; Zvonok, Nikolai; Locke, K'ara; Qu, Lu; Han, Gye Won; Iyer, Malliga R.; Cinar, Resat; Coffey, Nathan J.; Wang, Jingjing; Wu, Meng; Katritch, Vsevolod; Zhao, Suwen; Kunos, George; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#.Crystal Structure of the Human Cannabinoid Receptor CB2.CELL. 24 Jan 2019. 176(3):459-+.

3. Hua, Tian# *; Li, Xiaoting; Wu, Lijie; Iliopoulos-Tsoutsouvas, Christos; Wang, Yuxia; Wu, Meng; Shen, Ling; Johnston, Christina A.; Nikas, Spyros P.; Song, Feng; Song, Xiyong; Yuan, Shuguang; Sun, Qianqian; Wu, Yiran; Jiang, Shan; Grim, Travis W.; Benchama, Othman; Stahl, Edward L.; Zvonok, Nikolai; Zhao, Suwen; Bohn, Laura M.; Makriyannis, Alexandros; Liu, Zhi-Jie#.Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G(i) Complex Structures.CELL. 20 Feb 2020. 180(4):655-+.

4. Peng, Yao*; McCorvy, John D.; Harpsoe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-Ping; Wu, Yiran; Shen, Ling; Bjorn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.#; Stevens, Raymond C.#; Liu, Zhi-Jie#.5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.CELL. 08 Feb 2018. 172(4):719-+.

5. Zhou, Yali*; Daver, Henrik; Trapkov, Boris; Wu, Lijie; Wu, Meng; Harpsoe, Kasper; Gentry, Patrick R.; Liu, Kaiwen; Larionova, Marina; Liu, Junlin; Chen, Na; Brauner-Osborne, Hans#; Gloriam, David E.#; Hua, Tian#; Liu, Zhi-Jie#.Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.CELL RESEARCH. 01 Dec 2021.

6. Hua, Tian*; Vemuri, Kiran; Nikas, Spyros P.; Laprairie, Robert B.; Wu, Yiran; Qu, Lu; Pu, Mengchen; Korde, Anisha; Jiang, Shan; Ho, Jo-Hao; Han, Gye Won; Ding, Kang; Li, Xuanxuan; Liu, Haiguang; Hanson, Michael A.; Zhao, Suwen#; Bohn, Laura M.#; Makriyannis, Alexandros#; Stevens, Raymond C.; Liu, Zhi-Jie#.Crystal structures of agonist-bound human cannabinoid receptor CB1.NATURE. 27 Jul 2017. 547(7664):468-+.

7. Song, Gaojie*; Yang, Dehua; Wang, Yuxia; de Graaf, Chris; Zhou, Qingtong; Jiang, Shanshan; Liu, Kaiwen; Cai, Xiaoqing; Dai, Antao; Lin, Guangyao; Liu, Dongsheng; Wu, Fan; Wu, Yiran; Zhao, Suwen; Ye, Li; Han, Gye Won; Lau, Jesper; Wu, Beili; Hanson, Michael A.; Liu, Zhi-Jie#; Wang, Ming-Wei#; Stevens, Raymond C.#.Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.NATURE. 08 Jun 2017. 546(7657):312-+.

8. Hua, Tian*; Vemuri, Kiran; Pu, Mengchen; Qu, Lu; Han, Gye Won; Wu, Yiran; Zhao, Suwen; Shui, Wenqing; Li, Shanshan; Korde, Anisha; Laprairie, Robert B.; Stahl, Edward L.; Ho, Jo-Hao; Zvonok, Nikolai; Zhou, Han; Kufareva, Irina; Wu, Beili; Zhao, Qiang; Hanson, Michael A.; Bohn, Laura M.; Makriyannis, Alexandros; Stevens, Raymond C.; Liu, Zhi-Jie#.Crystal Structure of the Human Cannabinoid Receptor CB1.CELL. 2016. 167(3):750-762.

9. Liu, Bing*; Ouyang, Songying; Makarova, Kira S.; Xia, Qiu; Zhu, Yanping; Li, Zhimeng; Guo, Li; Koonin, Eugene V.; Liu, Zhi-Jie; Huang, Li.A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase.NATURE COMMUNICATIONS. 2015. 6:-.

10. Zhao, Lixia*; Hua, Tian; Crowley, Christopher; Ru, Heng; Ni, Xiangmin; Shaw, Neil; Jiao, Lianying; Ding, Wei; Qu, Lu; Hung, Li-Wei; Huang, Wei; Liu, Lei; Ye, Keqiang; Ouyang, Songying; Cheng, Genhong; Liu, Zhi-Jie#.Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.CELL RESEARCH. Mar 2014. 24(3):344-358.

11. Niu, Fengfeng*; Shaw, Neil; Wang, Yao E.; Jiao, Lianying; Ding, Wei; Li, Xiaomin; Zhu, Ping; Upur, Halmurat; Ouyang, Songying; Cheng, Genhong; Liu, Zhi-jie.Structure of the Leanyer orthobunyavirus nucleoprotein-RNA complex reveals unique architecture for RNA encapsidation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013. 110(22):9054-9059.

12. Ru, Heng*; Ni, Xiangmin; Zhao, Lixia; Crowley, Christopher; Ding, Wei; Hung, Li-Wei; Shaw, Neil; Cheng, Genhong; Liu, Zhi-Jie.Structural basis for termination of AIM2-mediated signaling by p202.CELL RESEARCH. 2013. 23(6):855-858.

13. Ouyang, Songying*; Song, Xianqiang; Wang, Yaya; Ru, Heng; Shaw, Neil; Jiang, Yan; Niu, Fengfeng; Zhu, Yanping; Qiu, Weicheng; Parvatiyar, Kislay; Li, Yang; Zhang, Rongguang; Cheng, Genhong; Liu, Zhi-Jie.Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding.IMMUNITY. 2012. 36(6):1073-1086.

14. Wu, Dong*; Li, Yang; Song, Gaojie; Cheng, Chongyun; Zhang, Rongguang; Joachimiak, Andrzej; Shaw, Neil#; Liu, Zhi-Jie#.Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues.CANCER RESEARCH. 2009. 69(18):7294-7301.

15. Shaw, Neil*; Zhao, Min; Cheng, Chongyun; Xu, Hao; Saarikettu, Juha; Li, Yang; Da, Yurong; Yao, Zhi; Silvennoinen, Olli; Yang, Jie; Liu, Zhi-Jie; Wang, Bi-Cheng; Rao, Zihe.The multifunctional human p100 protein 'hooks' methylated ligands.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2007. 14(8):779-784.

专著

专利

项目

奖励

  • 1. 2009,亚洲晶体学会理事

课题组成员

课题组合影

工作内容