师资队伍

Staff

Faculty KMS Profile
Raymond Stevens Founding Director
Degree ： Affiliation ： Position ： Adjunct Professor Honor ： Final education ： Graduate School ： Tel ：20685006 Fax ： Office ： Add ： Email ：stevens@shanghaitech.edu.cn Research Group： Group Website： Research Area：Imaging across scales, structure biology

Education Background

  • 1982-1986, University of Southern Maine, B.A.
  • 1986/9-1988/12, University of Southern California, PhD

Working Experience

  • 1/1989-6/1992, Harvard University, Postdoctoral Fellow
  • 9/1992-6/1999, University of California, Berkeley, Assistant Professor of Chemistry
  • 6/1999-7/2014, The Scripps Research Institute, Professor, Department of Integrative Structural and Computational Biology (formerly Department of Molecular Biology) and Department of Chemistry
  • 12/1999-11/2004, Joint Center for Structural Genomics, Founding Scientist
  • 2000-2005, Structural Proteomics in Europe (SPinE), Oxford University, Scientific Advisory Board
  • 11/2007-7/2014, Novo Nordisk Foundation Centre for Protein Research, Scientific Advisory Board
  • 2008-7/2014, National PKU Alliance, Scientific Advisory Board
  • 8/2008-7/2012, Receptos, Inc., Founding Scientist and Board of Directors
  • 7/2010-6/2016, GPCR Network, Founding Scientist and Director
  • 8/2011-7/2013, Shanghai Institute of Materia Medica, Shanghai, China, Chinese Academy of Sciences Senior Distinguished Visiting Professor
  • 7/2014-8/2021, Bridge Institute, University of Southern California, Founding Director
  • 10/2014-8/2021, Keck School of Medicine, University of Southern California, Professor of Physiology and Biophysics
  • 7/2010-present, NIH Study Section: Biological Chemistry and Macromolecular Biophysics (BBM), member
  • 7/2011-present, RuiYi, Inc (Shanghai, China), Founding Scientist and Chairman Board of Directors
  • 8/2012-present, iHuman Institute, ShanghaiTech University (Shanghai, China), Founding Director and Adjunct Professor
  • 6/2016-present, Structure Therapeutics, (Shanghai, China), Founding Scientist
  • 2/2017-present, Danaher Corporation, Board of Directors
  • 6/2019-present, University of Southern Maine Foundation, Board Member

Research Interests


We use an imaging across scales approach to investigate the path of insulin biosynthesis, trafficking, secretion, and recycling in pancreatic β-cell during glucose and drug stimulation. This approach will allow us to see at what points in this system the insulin secretion pathway breaks down as many questions remain. By integrating the multiple levels of research, our goal is to have a comprehensive picture of diabetes and related metabolic diseases, to provide the basis for next generation drug and cell-therapy design.


Research Achievement

Raymond Stevens' research group has made significant achievements in the field of structural and functional studies of G protein-coupled receptor (GPCR) related to essential human diseases such as diabetes and obesity (Science, 2020; Nature Communication, 2020; Nature, 2017). In recent years, our research group has targeted pancreatic islet β-cells, which play a key role in blood glucose regulation, and opened the boundaries of atomic, molecular, cellular, tissue and in vivo studies by means of imaging across scales. Part of our studies on the dynamic function of islet β-cells under physiological and pathological conditions have been published in Science Advances, 2020a; Science Advances, 2020b; Proc Natl Acad Sci U S A., 2022.

Raymond Stevens also actively contributes to translational research, with several medicines discovered/developed: Nesina, Kuvan, Pegvilase, Zeposia, Botox.


Representative Publications

·       1.Zeng Y, Yang K, Cui Y, Zhu X, Li R, Zhang H, Wu D, Stevens RC., Hu J, Zhou N*. Conjunctive encoding of exploratory intentions and spatial information in the hippocampus. Nat Commun.,2024, 15(1):3221.

·       2.Yuan S, Xia L, Wang C, Wu F, Zhang B, Pan C, Fan Z, Lei X, Stevens RC, Sali A, Sun L*., Shui W*. Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling. ACS Cent Sci.2023, 9(5):992-1007.

·       3.Xin Y, Liu S, Liu Y, Qian Z, Liu H, Zhang B, Guo T, Thompson GJ, Stevens RC, Sharpless KB*, Dong J*, Shui W*. Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor. Proc Natl AcadSci U S A,2023 120(11):e2220767120.

·       4.Wan W, Qin Q, Xie L, Zhang H, Wu F, Stevens RC*, Liu Y*. GLP-1R Signaling and Functional Molecules in Incretin Therapy. Molecules,2023, 28(2):751.

·       5.Zhang M, Qin Q, Zhang S, Liu W, Meng H, Xu M, Huang X, Lin X, Lin M, Herman P, Hyder F, Stevens RC, Wang Z, Li B*, Thompson, GJ*. Aerobic glycolysis imaging of epileptic foci during the inter-ictal period.EBioMedicine,2022,79:104004.

·       6.Amin Guo, Jianhua Zhang, Bo He, Angdi Li, Tianxiao Sun, Weimin Li, Jian Wang, Renzhong Tai, Yan Liu, Zhen Qian, Jiadong Fan*, Andrej Sali, Raymond C Stevens, Huaidong Jiang*, Quantitative, in situ visualization of intracellular insulin vesicles in pancreatic beta cells, Proc Natl Acad Sci U S A., 2022, 119(32):1-10.

·       7.Raveh B, Sun L, White KL, Sanyal T, Tempkin J, Zheng D, Bharath K, Singla J, Wang C, Zhao J, Li A, Graham NA, Kesselman C, Stevens RC, Sali A*. Bayesian metamodeling of complex biological systems across varying representations.Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2104559118.

·       8.Martin C, Gimenez LE, Williams SY, Jing Y, Wu Y, Hollanders C, Van der Poorten O, Gonzalez S, Van Holsbeeck K, Previti S, Lamouroux A, Zhao S, Tourwé D, Stevens RC*, Cone RD*, Ballet S*. Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure. J Med Chem.2021 Jan 14;64(1):357-369.

·       9.Hu T, Zheng G, Xue D, Zhao S, Li F, Zhou F, Zhao F, Xie L, Tian C, Hua T, Zhao S, Xu Y, Zhong G, Liu ZJ, Makriyannis A, Stevens RC, Tao H*. Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools. J Med Chem. 2021 Sep 23;64(18):13752-13765.

·       10.Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE*, Yang D*, Zhao L*, Wang MW*. Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor. Elife. 2021 Jul 13;10:e68719.

·       11.Li A, Zhang X, Singla J, White K, Loconte V, Hu C, Zhang C, Li S, Li W, Francis JP, Wang C, Sali A, Sun L*, He X*, Stevens RC*. Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion. PLoS One. 2022 Mar 24;17(3):e0265567.

·       12.White, Kate L.,Sali, Andrej;Larabell, Carolyn;Stevens, Raymond C.;,White, Kate L.;Singla, itin;Loconte, Valentina;Chen, Jian-Hua;Ekman, Axel;Sun, Liping;Zhang, Xianjun;Francis, John Paul;Li, Angdi;Lin, Wen;Tseng, Kaylee;McDermott, Gerry;Alber, Frank;Sali, Andrej*;Larabell, Carolyn*;Stevens, Raymond C*.,Visualizing subcellular rearrangements in intact beta cells using soft x-ray tomography,SCIENCE ADVANCES,Dec 2020,6(50).

·       13.Zhang, X.;Carter, S. D.;Singla, J.;White, K.L.;Butler, P. C.;Stevens, R.C.*, Jensen, G. J*.Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography.Sci Adv,2020,6(50): eabc8258.

·       14.Yu, Jing;Gimenez, Luis E.;Hernandez, Ciria C.;Wu, Yiran;Wein, Ariel H.;Han, Gye Won;McClary, Kyle;Mittal, Sanraj R.;Burdsall, Kylie;Stauch, Benjamin;Wu, Lijie;Stevens, Sophia N.;Peisley, Alys;Williams, Savannah Y.;Chen, Valerie;Millhauser, Glenn L.;Zhao, Suwen;Cone, Roger D*.;Stevens, Raymond C*.,Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding,SCIENCE,24 Apr 2020,368(6489).

·       15.Wu, Fan;Yang, Linlin;Hang, Kaini;Laursen, Mette;Wu, Lijie;Han, Gye Won;Ren, Qiansheng;Roed, Nikolaj Kulahin;Lin, Guangyao;Hanson, Michael A.;Jiang, Hualiang;Wang, Ming-Wei;Reedtz-Runge, Steffen;Song, Gaojie*;Stevens, Raymond C*.,Full-length human GLP-1 receptor structure without orthosteric ligands,NATURE COMMUNICATIONS,09 Mar 2020,11(1).

·       16.Peng, Yao;McCorvy, John D.;Harpsoe, Kasper;Lansu, Katherine;Yuan, Shuguang;Popov, Petr;Qu, Lu;Pu, Mengchen;Che, Tao;Nikolajsen, Louise F.;Huang, Xi-Ping;Wu, Yiran;Shen, Ling;Bjorn-Yoshimoto, Walden E.;Ding, Kang;Wacker, Daniel;Han, Gye Won;Cheng, Jianjun;Katritch, Vsevolod;Jensen, Anders A.;Hanson, Michael A.;Zhao, Suwen;Gloriam, David E.;Roth, Bryan L*.;Stevens, Raymond C*.;Liu, Zhi-Jie*,5-HT2C Receptor Structures Reveal the Structural Basis of GPCR. Polypharmacology,CELL,08 Feb 2018,172(4).

·       17.Hua, Tian;Vemuri, Kiran;Nikas, Spyros P.;Laprairie, Robert B.;Wu, Yiran;Qu, Lu;Pu, Mengchen;Korde, Anisha;Jiang, Shan;Ho, Jo-Hao;Han, Gye Won;Ding, Kang;Li, Xuanxuan;Liu, Haiguang;Hanson, Michael A.;Zhao, Suwen*;Bohn, Laura M.*;Makriyannis, Alexandros*;Stevens, Raymond C.;Liu, Zhi-Jie*,Crystal structures of agonist-bound human cannabinoid receptor CB1,NATURE,27 Jul 2017,547(7664).

·       18.Zhang, Haonan,Jiang, Hualiang;Wang, Ming-Wei;Wu, Beili;,Zhang, Haonan;Qiao, Anna;Yang, Dehua;Yang, Linlin;Dai, Antao;De Graaf, Chris;Reedtz-Runge, Steffen;Dharmarajan, Venkatasubramanian;Zhang, Hui;Han, Gye Won;Grant, Thomas D.;Sierra, Raymond G.;Weierstall, Uwe;Nelson, Garrett;Liu, Wei;Wu, Yanhong;Ma, Limin;Cai, Xiaoqing;Lin, Guangyao;Wu, Xiaoai;Geng, Zhi;Dong, Yuhui;Song, Gaojie;Griffin, Patrick R.;Lau, Jesper;Chrezov, Vadim;Yang, Huaiyu;Hanson, Michael A.;Stevens, Raymond C.;Zhao, Qiang;Jiang, Hualiang*;Wang, Ming-Wei*;Wu, Beili*,Structure of the full-length glucagon class B G-protein-coupled receptor,NATURE,08 Jun 2017,546(7657).

·       19.Wu, Fan;Song, Gaojie;de Graaf, Chris;Stevens, Raymond C.*,Structure and Function of Peptide-Binding G Protein-Coupled Receptors.2017.06.022,JOURNAL OF MOLECULAR BIOLOGY,18 Aug 2017,429(17):2726-2745.

·       20.Song, Gaojie;Yang, Dehua;Wang, Yuxia;de Graaf, Chris;Zhou, Qingtong;Jiang, Shanshan;Liu, Kaiwen;Cai, Xiaoqing;Dai, Antao;Lin, Guangyao;Liu, Dongsheng;Wu, Fan;Wu, Yiran;Zhao, Suwen;Ye, Li;Han, Gye Won;Lau, Jesper;Wu, Beili;Hanson, Michael A.;Liu, Zhi-Jie*;Wang, Ming-Wei*;Stevens, Raymond C.*,Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, NATURE,08 Jun 2017,546(7657):312

·       21.Hua, Tian;Vemuri, Kiran;Pu, Mengchen;Qu, Lu;Han, Gye Won;Wu, Yiran;Zhao, Suwen;Shui, Wenqing;Li, Shanshan;Korde, Anisha;Laprairie, Robert B.;Stahl, Edward L.;Ho, Jo-Hao;Zvonok, Nikolai;Zhou, Han;Kufareva, Irina;Wu, Beili;Zhao, Qiang;Hanson, Michael A.;Bohn, Laura M.;Makriyannis, Alexandros;Stevens, Raymond C.;Liu, Zhi-Jie*,Crystal Structure of the Human Cannabinoid Receptor CB1,CELL,2016,167(3):750-762.

 

Monograph

Patent

Funding

Awards

Group Member

  • Name：Liu Yan
    Position：Research associate Professor
    Duration：
    Email：liuyan2@shanghaitech.edu.cn
  • Name：Xie Linshan
    Position：PhD candidate
    Duration：2018
    Email：xielsh@shanghaitech.edu.cn
  • Name：Zhuang Lu
    Position：PhD candidate
    Duration：2019
    Email：zhuanglu@shanghaitech.edu.cn
  • Name：Li Rui
    Position：PhD candidate
    Duration：2019
    Email：lirui2@shanghaitech.edu.cn
  • Name：Zeng Yifan
    Position：PhD candidate
    Duration：2020
    Email：zengyf1@shanghaitech.edu.cn
  • Name：Wan Wenwei
    Position：M.S.
    Duration：2020
    Email：wanww@shanghaitech.edu.cn
  • Name：Fang Xiaoyu
    Position：M.S.
    Duration：2021
    Email：fangxy1@shanghaitech.edu.cn
  • Name：Xu Rong
    Position：M.S.
    Duration：2021
    Email：xurong@shanghaitech.edu.cn
  • Name：Xu Lin
    Position：M.S.
    Duration：2021
    Email：xulin@shanghaitech.edu.cn
  • Name：Wang Yan
    Position：M.S.
    Duration：2023
    Email：wangyan2023@shanghaitech.edu.cn
  • Name：Zhao Yuwei
    Position：M.S.
    Duration：2023
    Email：zhaoyw2023@shanghaitech.edu.cn

Group Photo


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