Kurt Wüthrich Distinguished Adjunct Professor
Degree :Ph.D. Affiliation : Position : Principal Investigator Honor : Final education : Graduate School : Tel : Fax : Office :Ren Bldg. A206 Add : Email :wuthrich@shanghaitech.edu.cn Research Group: Group Website: Research Area:Biomolecular NMR spectroscopy in solution

Education Background

Working Experience

Research Interests

1. Biomolecular NMR spectroscopy in solution
2. Function-related polymorphisms and rate processes in GPCRs and other biological systems

3. Drug discovery supported by solution NMR

4. Imaging across scales – integrate NMR with MRI and other techniques


Research Achievement

Molecules. 2023, 28(14):5419





J Am Chem Soc. 2023, 145(28):15061-15064.


iScience. 2023, 26(6):106918.



MedComm. 2023, 10;4(2):e260.



Representative Publications

1.  Guo, C., Yang, L., Liu, Z., Liu, D. & Wüthrich, K. (2023) Two-Dimensional NMR Spectroscopy of the G Protein-Coupled Receptor A(2A)AR in Lipid Nanodiscs, Molecules. 28.

2.  Zhang, J., Feng, D., Cheng, J. & Wüthrich, K. (2023) Adenosine A(2A) Receptor (A(2A)AR) Ligand Screening Using the (19)F-NMR Probe FPPA, J Am Chem Soc. 145, 15061-15064.

3.  Wang, H., Hu, W., Xu, T., Yuan, Y., Liu, D. & Wüthrich, K. (2023) Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR, iScience. 26, 106918.

4.  Fan, Y., Lin, X., Pan, B., Chen, B., Liu, D., Wüthrich, K. & Xu, F. (2023) Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by (19)F-NMR and cryo-electron microscopy, MedComm (2020). 4, e260.

5.  Pan, B., Liu, D., Yang, L. & Wüthrich, K. (2022) GPCR large-amplitude dynamics by (19)F-NMR of aprepitant bound to the neurokinin 1 receptor, Proc Natl Acad Sci U S A. 119, e2122682119.

6.  Ge, H., Wang, H., Pan, B., Feng, D., Guo, C., Yang, L., Liu, D. & Wüthrich, K. (2022) G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling, Molecules. 27.

7.  Wüthrich, K. (2021) Brownian motion, spin diffusion and protein structure determination in solution, J Magn Reson. 331, 107031.

8.  Wang, H., Hu, W., Liu, D. & Wüthrich, K. (2021) Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for (19) F-NMR studies in solution, Febs j. 288, 4053-4063.

9.  Zhang, J., Yan, W., Duan, W., Wüthrich, K. & Cheng, J. (2020) Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists, Pharmaceuticals (Basel). 13.

10.  Shimada, I., Ueda, T., Kofuku, Y., Eddy, M. T. & Wüthrich, K. (2019) GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures, Nat Rev Drug Discov. 18, 59-82.

11.  Chen, S., Lu, M., Liu, D., Yang, L., Yi, C., Ma, L., Zhang, H., Liu, Q., Frimurer, T. M., Wang, M. W., Schwartz, T. W., Stevens, R. C., Wu, B., Wüthrich, K. & Zhao, Q. (2019) Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography, Nat Commun. 10, 638.

12.  Eddy, M. T., Lee, M. Y., Gao, Z. G., White, K. L., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K. M., Han, G. W., Jacobson, K. A., Stevens, R. C. & Wüthrich, K. (2018) Allosteric Coupling of Drug Binding and Intracellular Signaling in the A(2A) Adenosine Receptor, Cell. 172, 68-80.e12.

13.  Liu, D. & Wüthrich, K. (2016) Ring current shifts in (19)F-NMR of membrane proteins, J Biomol NMR. 65, 1-5.

14.  Liu, J. J., Horst, R., Katritch, V., Stevens, R. C. & Wüthrich, K. (2012) Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR, Science. 335, 1106-10.


Monograph

Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, Wiley, New York.

Wüthrich, K. (2021) NMR with Biological Macromolecules in Solution, World Scientific, Singapore.


Patent

Funding

Awards

Group Member

  • Name:Dongsheng Liu
    Position:Res. Assoc. Prof.
    Duration:
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  • Name:Xiaoqian Bai
    Position:Engineer
    Duration:
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  • Name:Dandan Feng
    Position:Ph.D student
    Duration:
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  • Name:Canyong Guo
    Position:Ph.D student
    Duration:
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  • Name:Haoyi Ge
    Position:Ph.D student
    Duration:
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  • Name:Chen Chen
    Position:Ph.D student
    Duration:
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  • Name:Chuanfeng Zheng
    Position:Ph.D student
    Duration:
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  • Name:Changran Chen
    Position:Ph.D student
    Duration:
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  • Name:Qiangqiang Zhang
    Position:Ph.D student
    Duration:
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  • Name:Xiaowen Li
    Position:Master student (Ph.D candidate)
    Duration:
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  • Name:Ziyao Yang
    Position:Master student (Ph.D candidate)
    Duration:
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Group Photo

Work