1. 溶液中的生物分子核磁共振(NMR)波谱

2. G蛋白偶联受体(GPCR)和其它生物系统中的功能相关多态性和速率过程

3. 使用溶液核磁共振支持药物发现

4. 多尺度成像 — 将核磁共振与磁共振成像(MRI)和其他技术相结合

Molecules. 2023, 28(14):5419

J Am Chem Soc. 2023, 145(28):15061-15064.

iScience. 2023, 26(6):106918.

MedComm. 2023, 10;4(2):e260.

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3.  Wang, H., Hu, W., Xu, T., Yuan, Y., Liu, D. & Wüthrich, K. (2023) Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR, iScience. 26, 106918.

4.  Fan, Y., Lin, X., Pan, B., Chen, B., Liu, D., Wüthrich, K. & Xu, F. (2023) Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by (19)F-NMR and cryo-electron microscopy, MedComm (2020). 4, e260.

5.  Pan, B., Liu, D., Yang, L. & Wüthrich, K. (2022) GPCR large-amplitude dynamics by (19)F-NMR of aprepitant bound to the neurokinin 1 receptor, Proc Natl Acad Sci U S A. 119, e2122682119.

6.  Ge, H., Wang, H., Pan, B., Feng, D., Guo, C., Yang, L., Liu, D. & Wüthrich, K. (2022) G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling, Molecules. 27.

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9.  Zhang, J., Yan, W., Duan, W., Wüthrich, K. & Cheng, J. (2020) Tumor Immunotherapy Using A(2A) Adenosine Receptor Antagonists, Pharmaceuticals (Basel). 13.

10.  Shimada, I., Ueda, T., Kofuku, Y., Eddy, M. T. & Wüthrich, K. (2019) GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures, Nat Rev Drug Discov. 18, 59-82.

11.  Chen, S., Lu, M., Liu, D., Yang, L., Yi, C., Ma, L., Zhang, H., Liu, Q., Frimurer, T. M., Wang, M. W., Schwartz, T. W., Stevens, R. C., Wu, B., Wüthrich, K. & Zhao, Q. (2019) Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography, Nat Commun. 10, 638.

12.  Eddy, M. T., Lee, M. Y., Gao, Z. G., White, K. L., Didenko, T., Horst, R., Audet, M., Stanczak, P., McClary, K. M., Han, G. W., Jacobson, K. A., Stevens, R. C. & Wüthrich, K. (2018) Allosteric Coupling of Drug Binding and Intracellular Signaling in the A(2A) Adenosine Receptor, Cell. 172, 68-80.e12.

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