课题组使用世界领先的膜蛋白结构生物学与生物化学、细胞生物学、药理学结合的方法，研究与人类胚胎发育及疾病发生密切

相关的一类信号转导受体-GPCR靶点，包括其蛋白结构，信号转导复合物结构与功能，以及药物小分子与抗体的筛选和验证等。

1.       Lin Xi, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F. Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun. 2023, 14(1):216. doi: 10.1038/s41467-023-35882-w.

2.       Yue Yang, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault É, Longpré JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F. Structural insight into apelin receptor-G protein stoichiometry. Nat Struct Mol Biol. 2022, 29(7):688-697

3.       Chen Yuxiang, Chen B, Wu T, Zhou F, Xu F. Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. Protein & Cell. pwac033, https://doi.org/10.1093/procel/pwac033.

4.       Zheng You, Liu H, Chen Y, Dong S, Wang F, Wang S, Li GL, Shu Y, Xu F. Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. Neuron. 2022, 19;110(2):237-247.

5.       Xu Lu, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F. Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. Cell Res. 2021, 31(12):1311-1314.

6.       Lin Xi, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F. Structural basis of ligand recognition and self-activation of orphan GPR52. Nature. 2020, 579(7797):152-157.

7.       Yang Shifan, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. 2018, 560(7720):666-670.

8.       Zhang Xianjun, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun. 2017, 8:15383.

9.       Ma Yingli, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F. Structural Basis for Apelin Control of the Human Apelin Receptor. Structure. 2017, 6;25(6):858-866.

10.   Zhang Xianjun, Dong S, Xu F. Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors. Trends Biochem Sci. 2018, 43(12): 1033-1046.

11.   Zhang Xianjun, Stevens R. C, Xu F. The importance of ligands for G protein-coupled receptor stability. Trends Biochem Sci, 2015, 40(2): 79-87.