Andrej Sali began an effort in computational structural biology that will contribute to the mapping of the human pancreatic beta cell (PBC). Our long term goal is to develop and apply integrative multi- scale modeling,1,2 based on heterogenous datasets generated by the PBC consortium and others. The effort is coordinated with the Sali research group at University of California, San Francisco, and Ray Stevens, the leader of the PBC project. Our key tool is the open source Integrative Modeling Platform (IMP) package (http:// integrativemodeling.org)3, which we will develop further in part as a result of activities at iHuman. To achieve our long term goal, weformulated the following four speci c aims: