iHuman INSTITUTE

Staff and Student

Staff and Student

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Raymond Stevens
Kurt Wüthrich
Professor, 2002 Nobel Laureate in Chemistry
Research Focus:Molecular Structural Biology
Email:wuthrich@scripps.edu
Office:Room C804,Ren Building, 393 Middle Huaxia Rd
Lab Page:group.ihuman-institute.org/wuthrich/

Current research of the iHuman NMR team led by Prof. Kurt Wu?thrich and Prof. Dongsheng Liu includes all aspects of biomolecular NMR spectroscopy in solution and structural interpretation of NMR data. The NMR equipment includes two new spectrometers operating at 1H frequencies of 600 and 800 MHz, with peripheral hardware for micro-coil experiments and high-sensitivity 19F-detection. The NMR team operates a molecular biology/biochemistry laboratory for functional and biophysical studies of proteins, in particular for investigations of G protein- coupled receptors (GPCRs) and their interaction proteins, and for the preparation of isotope-labeled proteins in supramolecular complexes for NMR studies. Present applications of solution NMR techniques include studies of the glucagon receptor (GCGR), the glucagon-like peptide-1 receptor (GLP-1R) and other GPCRs, where a special focus is on studies of function-related local polymorphisms, and on dynamic processes governing transitions between locally different conformations in inactive and activate-like states of GPCRs.