Zhao Suwen’s group currently focuses on the study of membrane protein signaling mechanisms and their ligand/drug discovery. Many membrane proteins such as G protein-coupled receptors have been intensively researched and have a lot of known ligands. However, where do these ligands bind and how do they bind are not known for most cases. We use docking, together with mutation data, SAR data, selectivity data and potentially many other data, to find binding sites and poses of known ligands of membrane proteins. Once we get the accurate binding poses, we try to understand the mechanism of these molecules. Once we understand the mechanism of these molecules, we have a very good background to do structure-based drug discovery/design for those targets, and to discover novel/allosteric/biased ligands.