The work reveals the structural features of antagonist-bound CB2 and the unique ligand binding mode, which will facilitate rational drug design toward precise modulation of the endocannabinoid system. These new findings are published in the prestigious journal Cell, titled “Crystal structure of the Human Cannabinoid Receptor CB2”.
The Symposium on Probing Protein Structures with Bio-MS and Complementary Technologies was held at ShanghaiTech University on November 18th, organized by Shui Wenjing Group of iHuman Institute and supported by Shanghai Institute for Advanced Studies, CAS.
On November 2nd, the 17th International Conference on the Crystallization of Biological Macromolecules (ICCBM17) and the 6th Annual iHuman Forum successfully concluded. Co- hosted by iHuman Institute and Northwestern Polytechnical University as well as Shanghai Biophysical Society, ICCBM is a well-recognized international academic conference affiliated to the International Organization for Biological Crystallization (IOBCr). Held every two years, it has a strong reputation in the scientific and technological community.
August 31, 2018 - Joachim Frank, the winner of the 2017 Nobel Laureate in Chemistry and a professor at Columbia University, was invited by Kurt Wüthrich, an adjunct professor at the iHuman Institute, to give a ShanghaiTech lecture titled "Single Particle Cryo-EM -- A Journey to High Resolution without Crystals.
August 23, 2018 - The Xu Laboratory at the iHuman Institute of ShanghaiTech University has deciphered the high-resolution crystal structure of the first human Frizzled receptor. As a gatekeeping protein in regulating the fundamental Wnt signaling in embryonic development and tumorigenesis, the Frizzled receptors (FZDs) have been cancer drug targets for decades without success.
August 16, 2018 - The Biophysical Society (BPS) has named Raymond Stevens, the Founding Director of iHuman Institute, ShanghaiTech University, Provost Professor and Director of the Bridge Institute, Department of Biological Sciences and Chemistry, University of Southern California, as its 2019 Anatrace Membrane Protein Award winner.
June 10, 2018 - In order to further promote university researchers in Shanghai, especially the outstanding talents, and cultivate a group of excellent researchers, Shanghai Education Development Foundation funded the establishment of Shanghai Youth Researchers Training Program (Chenguang Plan).
June 8, 2018 - The iHuman research paper “Crystal Structure of the Human Cannabinoid Receptor CB1” has been selected as the “Best of Cell 2017”, which celebrates editors’ and readers’ favorites of ground-breaking research published in Cell.
June 1, 2018 – The Roche-RSC International Symposium on Scientific Frontiers to Enable Drug Discovery was successfully held in ShanghaiTech University, hosted by F. Hoffmann-la Roche AG (Roche) and the Royal Society of Chemistry (RSC) and co-organized by ShanghaiTech University and Shanghai Institute of Biophysics. It was jointly chaired by Dr. Shen Hong, head of Medicinal Chemistry at Roche Innovation Center Shanghai, and Professor Liu Zhijie, executive director of ShanghaiTech’s iHuman Institute. Nearly 720 attendees from chemical and biology-related fields representing more than ten academic colleges, universities, scientific research institutes and industrial companies and attended the symposium.
May 1, 2018 - Professor Andrej Sali, Professor at the University of California, San Francisco and Adjunct Professor at the iHuman Institute, has been is elected as a member of National Academy of Sciences.