Research

Research

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1.     

Liu, K.Wu, L., Yuan, S., Wu, M.Xu, Y.Sun, Q., Li, S., Zhao, S.Hua, T., and Liu, Z.J. (2020). Structural basis of CXC chemokine receptor 2 activation and signalling. Nature.

2.     

Yu, J., Gimenez, L.E., Hernandez, C.C., Wu, Y., Wein, A.H., Han, G.W., McClary, K., Mittal, S.R., Burdsall, K., Stauch, B., Wu, L.Stevens, S.N., Peisley, A., Williams, S.Y., Chen, V., Millhauser, G.L., Zhao, S., Cone, R.D., and Stevens, R.C. (2020). Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding. Science 368, 428.

3.     

Lin, X., Li, M., Wang, N.Wu, Y., Luo, Z., Guo, S., Han, G.W., Li, S., Yue, Y., Wei, X., Xie, X., Chen, Y., Zhao, S., Wu, J., Lei, M., and Xu, F. (2020). Structural basis of ligand recognition and self-activation of orphan GPR52. Nature 579, 152-157.

4.     

Hua, T.Li, X.Wu, L., Iliopoulos-Tsoutsouvas, C., Wang, Y.Wu, M.Shen, L., Johnston, C.A., Nikas, S.P., Song, F., Song, X., Yuan, S., Sun, Q.Wu, Y., Jiang, S., Grim, T.W., Benchama, O., Stahl, E.L., Zvonok, N., Zhao, S., Bohn, L.M., Makriyannis, A., and Liu, Z.J. (2020). Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures. Cell 180, 655-665 e618.

5.     

Wang, J.Hua, T., and Liu, Z.J. (2020). Structural features of activated GPCR signaling complexes. Curr Opin Struct Biol 63, 82-89.

6.     

Tan, L.Zhou, Q.Yan, W.Sun, J., Kozikowski, A.P., Zhao, S., Huang, X.P., and Cheng, J. (2020). Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands. J Med Chem 63, 4579-4602.

7.     

Lou, R.Tang, P.Ding, K.Li, S.Tian, C., Li, Y., Zhao, S., Zhang, Y., and Shui, W. (2020). Hybrid Spectral Library Combining DIA-MS Data and a Targeted Virtual Library Substantially Deepens the Proteome Coverage. iScience 23, 100903.

8.     

Xia, L.Ma, Z.Tong, J., Tang, Y., Li, S.Qin, S.Lou, R.Zhao, S., Lei, X., and Shui, W. (2020). Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry. Anal Chim Acta 1102, 53-62.

9.     

Wu, F., Yang, L., Hang, K., Laursen, M., Wu, L., Han, G.W., Ren, Q., Roed, N.K., Lin, G., Hanson, M.A., Jiang, H., Wang, M.W., Reedtz-Runge, S., Song, G., and Stevens, R.C. (2020). Full-length human GLP-1 receptor structure without orthosteric ligands. Nat Commun 11, 1272.

10.     

Wang, J.Wu, M.Wu, L.Xu, Y.Li, F.Wu, Y., Popov, P., Wang, L., Bai, F., Zhao, S.Liu, Z.J., and Hua, T. (2020). The structural study of mutation-induced inactivation of human muscarinic receptor M4. IUCrJ 7, 294-305.

11.     

Zhang, B.Zhao, S., Yang, D., Wu, Y.Xin, Y.Cao, H., Huang, X.P., Cai, X., Sun, W., Ye, N., Xu, Y.Peng, Y.Zhao, S.Liu, Z.J.Zhong, G., Wang, M.W., and Shui, W. (2020). A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts. ACS Cent Sci 6, 213-225.

12.     

Pu, J., Liu, Y., Zhang, J., An, B., Li, Y., Wang, X., Din, K., Qin, C., Li, K., Cui, M., Liu, S., Huang, Y., Wang, Y., Lv, Y., Huang, J., Cui, Z., Zhao, S., and Zhong, C. (2020). Virus Disinfection from Environmental Water Sources Using Living Engineered Biofilm Materials. Advanced Science.

13.     

Sanganahalli, B.G., Baker, K.L., Thompson, G.J., Herman, P., Shepherd, G.M., Verhagen, J.V., and Hyder, F. (2020). Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. Neuroimage 212, 116664.

14.     

Xu, L. , Tong, J. , Wu, Y. Zhao, S. , & Lin, B. . (2020). Targeted Oxidation Strategy (TOS) for Potential Inhibition of Coronaviruses by Disulfiram — a 70-Year Old Anti- Alcoholism Drug. 

15.     

Liu, C., Xia, L., Fu, K., Cao, X., Yan, W.Cheng, J., Roux, T., Peletier, L.A., Yin, X., and Guo, D. (2020). Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective. Eur J Pharmacol 880, 173157.

16.     

Tong, B., Wang, J., Cheng, Z., Liu, J., Wu, Y., Li, Y., Bai, C., Zhao, S., Yu, H., and Li, G. (2020). Novel Variants in GDF9 Gene Affect Promoter Activity and Litter Size in Mongolia Sheep. Genes (Basel) 11.

17.     

Zhang, B., Tastan, O.Y., Zhou, X., Guo, C.J., Liu, X., Thind, A., Hu, H.H., Zhao, S., and Liu, J.L. (2020). The proline synthesis enzyme P5CS forms cytoophidia in Drosophila. J Genet Genomics 47, 131-143.

18.     

Fan, L., Tan, L., Chen, Z., Qi, J., Nie, F., Luo, Z., Cheng, J., and Wang, S. (2020). Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands. Nat Commun 11, 1074.

19.     

Mao, Q., Zhang, B., Li, W., Tian, S., Shui, W., and Ye, N. (2020). Identification of Novel 1-O-Substituted Aporphine Analogues as Potent 5-HT2C Receptor Agonists. ACS Chem Neurosci 11, 549-559.

20.     

Chan, H.C.S., Xu, Y.Tan, L., Vogel, H., Cheng, J.Wu, D., and Yuan, S. (2020). Enhancing the Signaling of GPCRs via Orthosteric Ions. ACS Cent Sci 6, 274-282.

21.     

Sun, W., Huo, Y., Mei, Y., Zhou, Q.Zhao, S., and Zhuang, M. (2020). Identification of a Small Probe That Can Be Conjugated to Proteins by Proximity Labeling. ACS Chem Biol 15, 39-43.

22.     

Sun, H., Zhou, Y., Skaro, M.F., Wu, Y., Qu, Z., Mao, F., Zhao, S., and Xu, Y. (2020). Metabolic Reprogramming in Cancer Is Induced to Increase Proton Production. Cancer Res 80, 1143-1155.

23.     

Zhang, Y., Zhang, H., Wang, Z., Wu, Z., Wang, Y., Tang, N., Xu, X.Zhao, S., Chen, W., and Ji, Q. (2020). Programmable adenine deamination in bacteria using a Cas9-adenine-deaminase fusion. Chem Sci 11, 1657-1664.