科学研究

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1.     

Yang S., Wu Y., Xu T.H., de Waal P.W., He Y., Pu M., Chen Y., Debruine Z.J., Zhang B., Zaidi S.A., Popov P., Guo Y., Han G.W., Lu Y., Suino-Powell K., Dong S., Harikumar K.G., Miller L.J., Katritch V., Xu H.E., Shui W., Stevens R.C., Melcher K., Zhao S., Xu F.,(2018). Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature, 

2.     

Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L.F., Huang, X., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., and Liu, Z. (2018). 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. CELL 172, 719-730.

3.     

Qiu, X., Huang, Y., Wu, D., Mao, F., Zhu, J., Yan, W., Luo, H., and Li, J. (2018). Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation. BIOORGAN MED CHEM 26, 119-133.

4.     

Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K.S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O.P., Hanson, M.A., Stevens, R.C., Wang, M., Reedtz-Runge, S., Jiang, H., Zhao, Q., and Wu, B. (2018). Structure of the glucagon receptor in complex with a glucagon analogue. NATURE 553, 106.

5.     

Ye, M., Yang, J., Tian, C., Zhu, Q., Yin, L., Jiang, S., Yang, M., and Shu, Y. (2018). Differential roles of Na(V)1.2 and Na(V)1.6 in regulating neuronal excitability at febrile temperature and distinct contributions to febrile seizures. SCI REP-UK 8.

6.     

Yan, X., Shi, Q., Bracher, A., Milicic, G., Singh, A.K., Hartl, F.U., and Hayer-Hartl, M. (2018). GroEL Ring Separation and Exchange in the Chaperonin Reaction. CELL 172, 605.

7.     

Johnson, F.K., Delpech, J., Thompson, G.J., Wei, L., Hao, J., Herman, P., Hyder, F., and Kaffman, A. (2018). Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. TRANSL PSYCHIAT 8.

8.     

Qin, S., Meng, M., Yang, D., Bai, W., Lu, Y., Peng, Y., Song, G., Wu, Y., Zhou, Q., Zhao, S., Huang, X., McCorvy, J.D., Cai, X., Dai, A., Roth, B.L., Hanson, M.A., Liu, Z., Wang, M., Stevens, R.C., and Shui, W. (2018). High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. CHEM SCI 9, 3192-3199.

9.     

Zhang, W., Sun, S., Yang, L., Lu, C., He, Y., Zhang, C., Cai, M., Yao, Y., Zhang, F., and Zhuang, X. (2018). Polymer nanosheets derived porous carbon nanosheets as high efficient electrocatalysts for oxygen reduction reaction. J COLLOID INTERF SCI 516, 9-15.

10.     

Li, Z., Li, Y., Chen, W., Cao, Q., Guo, Y., Wan, N., Jiang, X., Tang, Y.J., Wang, Q., and Shui, W. (2018). Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic C-13-Labeling Metabolism Analysis (vol 89, pg 877, 2017). ANAL CHEM 90, 5509.

11.     

Shang, W., Jiang, Y., Boettcher, M., Ding, K., Mollenauer, M., Liu, Z., Wen, X., Liu, C., Hao, P., Zhao, S., McManus, M.T., Wei, L., Weiss, A., and Wang, H. (2018). Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. P NATL ACAD SCI USA 115, E4051-E4060.

12.     

Yang, Z., Han, S., Keller, M., Kaiser, A., Bender, B.J., Bosse, M., Burkert, K., Koegler, L.M., Wifling, D., Bernhardt, G., Plank, N., Littmann, T., Schmidt, P., Yi, C., Li, B., Ye, S., Zhang, R., Xu, B., Larhammar, D., Stevens, R.C., Huster, D., Meiler, J., Zhao, Q., Beck-Sickinger, A.G., Buschauer, A., and Wu, B. (2018). Structural basis of ligand binding modes at the neuropeptide Y Y-1 receptor. NATURE 556, 520.

13.     

Xiao, W., Duan, X., Lin, Y., Cao, Q., Li, S., Guo, Y., Gan, Y., Qi, X., Zhou, Y., Guo, L., Qin, P., Wang, Q., and Shui, W. (2018). Distinct Proteome Remodeling of Industrial Saccharomyces cerevisiae in Response to Prolonged Thermal Stress or Transient Heat Shock. J PROTEOME RES 17, 1812-1825.

14.     

Vass, M., Kooistra, A.J., Yang, D., Stevens, R.C., Wang, M., and de Graaf, C. (2018). Chemical Diversity in the G Protein-Coupled Receptor Superfamily. TRENDS PHARMACOL SCI 39, 494-512.

15.     

Liu, X., Gao, Z., Wu, Y., Stevens, R.C., Jacobson, K.A., and Zhao, S. (2018). Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y(1 )and P2Y(12) receptors. SCI REP-UK 8.

16.     

Huang, L., Tong, X., Wang, F., Luo, L., Jin, R., Fu, Y., Zhou, G., Li, D., Song, G., Liu, Y., and Zhu, F. (2018). Novel mutations in PATL2 cause female infertility with oocyte germinal vesicle arrest. HUM REPROD 33, 1183-1190.

17.     

Qiu, B., Xia, B., Zhou, Q., Lu, Y., He, M., Hasegawa, K., Ma, Z., Zhang, F., Gu, L., Mao, Q., Wang, F., Zhao, S., Gao, Z., and Liao, J. (2018). Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate. CELL RES 28, 644-654.