Shang Weifeng group’s current research focuses on the design and commissioning of a world-class synchrotron radiation macromolecular crystallography (MX) beamline optimized for structural studies of membrane proteins. In the past decades, X-ray crystallography remains the most important technique for elucidating the detailed structural features of proteins. Most membrane proteins including G-protein coupled receptors (GPCRs) form notoriously small, weakly diffracting, radiation-sensitive crystals. Therefore these crystals are intractable to traditional crystallography beamlines, e.g. several operational beamlines at Shanghai Synchrotron Radiation Facility (SSRF). The latest revolution in crystallography benefits from the development of dedicated beamlines with brilliant X-ray beams focused down to microns and micro-crystallography opened up exciting areas of research because many previously intractable samples can be used for structural determination. The Phase-II beamline construction project at SSRF gives an opportunity to address the growing needs for macromolecular microcrystallography. A new micro-beam MX beamline optimized for membrane protein crystals will be built and planned for operation in late 2019.