Guisheng Zhong Research Associate Professor


InstituteiHuman Institute
Research AreaCellular Structural Biology and Bioimaging

Dr. Zhong got the bachelor degree of physics at Anhui University at 1999; got the master degree of Biophysics at University of Science and Technology of China at 2002 and received his PhD degree of Neurobiology and Behavior at Cornell University at 2007. From 2007-2015, Dr. Zhong received his postdoctoral training in the field of neurobiology and superresolution fluorescence imaging at Cornell University and Harvard University. From 2015, Dr. Zhong joined ShanghaiTech university as an assistant professor at school of life science and technology and as a research associate professor at iHuman institute.

helix2Research Interests
Dr. Zhong’s group is studing the following biological questions using superresolution fluorescence imaging and electrophyiology methods: 1) the structure and function of GPCR in cells; 2) the organization mechanism of neural ciruits for locomotion; 3 the communication mechanism between microglia and neurons. We are also interested in developing new imaging methods with STORM and X-ray.
bookSelected Publications

(1) Zhong G#, He J#, Zhou R, Lorenzo DN, Babcock HP, Bennett V & Zhuang X. (2015) The formation of a periodic cytoskeleton structure in neurons during development. Elife e04581.

(2) Xu K#, Zhong G # & Zhuang X. (2013) Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons. Science 339: 452-456. 

(3) Shim SH, Xia C, Zhong G , Babcock HP, Vaughan JC, Huang B, Wang X, Xu C, Bi G-Q & Zhuang X. (2012) Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes. PNAS 109: 13978-13983.

(4) Zhong G , Shevtsova NA, Rybak IA & Harris-Warrick RM. (2012) Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: Insights into locomotor CPG organization. J Physiol 590: 4735-4759

(5) Abbinanti MD, Zhong G & Harris-Warrick RM. (2012) Postnatal Emergence of Serotonin-Induced Plateau Potentials in Commissural Interneurons of the Mouse Spinal Cord. J Neurophysiol 108: 2191-2202.

(6) Zhong G , Sharma K & Harris-Warrick RM. (2011) Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord. Nature Commun 2: 274.

(7) Zhong G , Droho S, Crone S, Dietz S, Kwan A, Webb WW, Sharma K & Harris-Warrick RM. (2010) Electrophysiological characterization of the V2a interneurons and their locomotor-related activity in the neonatal mouse spinal cord. J Neurosci 30: 170-182.

(8) Kwan AC, Dietz SB, Zhong G , Harris-Warrick RM & Webb WW. (2010) Spatiotemporal dynamics of rhythmic spinal interneurons measured with two-photon calcium imaging and coherence analysis. J Neurophysiol 104: 3323-3333. 

(9) Crone S#, Zhong G #, Harris-Warrick RM & Sharma, K. (2009) In mice lacking V2a interneurons, gait depends on speed of locomotion. J Neurosci 29: 7098-7109. 

(10) Zhong G , Masino MA & Harris-Warrick RM. (2007) Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord. J Neurosci 27: 4507-4518.