|2004 B. Eng. Department of Polymer Science and Engineering, University of Science and Technology of China|
2009 Ph.D. Department of Chemistry, Columbia University
2010-2014 Postdoctoral Researcher, Department of Pharmaceutical Chemistry, University of California, San Francisco
2014 Research Associate Professor, iHuman Institute & Assistant Professor, School of Life Science & Technology, ShanghaiTech University
|GPCR full length structure prediction; ligand prediction for GPCR and other cell signaling proteins|
S. Zhao, R. Kumar, A. Sakai, M. W. Vetting, B. M. Wood, S. Brown, J. B. Bonanno, B. S. Hillerich, R. D. Seidel, P. C. Babbitt, S. C. Almo, J. V. Sweedler, J. A. Gerlt, J. E. Cronan, and M. P. Jacobson, “Discovery of new enzymes and metabolic pathways by using structure and genome context”, Nature, 502, 698-702 (2013).
S. Zhao, A. Sakai, X. Zhang, M. W. Vetting, R. Kumar, B. Hillerich, B. San Francisco, J. Solbiati, A. Steves, S. Brown, E. Akiva, A. Barber, R. D. Seidel, P. C. Babbitt, S. C. Almo, J. A. Gerlt and M. P. Jacobson, “Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks”, eLife, e03275 (2014).
M. P. Jacobson, C. Kalyanaraman, S. Zhao and B. Tian, “Leveraging structure for enzyme function prediction: methods, opportunities, and challenges”, Trends Biochem. Sci.,39(8), 363-71 (2014).
R. Kumar, S. Zhao, A. Sakai, M. W. Vetting, B. M. Wood, S. C. Almo, J. V. Sweedler, J. A. Gerlt, J. E. Cronan, and M. P. Jacobson, “Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant, proline betaine”, mBio,5, (2014).
S. Zhao, K. Zhu, J. Li, R. A. Friesner, “Progress in super long loop prediction”, Proteins, 79, 2920-2935 (2011).