Fei Xu Research Associate Professor


InstituteiHuman Institute
Research AreaCell Biology
Contactxufei@shanghaitech.edu.cn,  Webpage 

-Sept 2013- present Research Associate Professor, iHuman Institute, ShanghaiTech University
Focused on GPCR signaling in stem cell development and cancer
-Sept 2012- Sept 2013 Scientific Consultant, RuiYi Inc., La Jolla, CA, USA
-Aug 2011- Sept 2012 Founder and Director, R&D
RuiYi Biopharmaceutics Technology Co., Ltd., Shanghai, China
Focused on biologic drug development targeting on GPCR
-July 2006- June 2011 Ph.D. in Biology
The Scripps Research Institute (TSRI), La Jolla, California, USA
-Sept 2002- July 2006 B.S. in Biological Sciences
University of Science and Technology of China (USTC), Hefei, China
helix2Research Interests
Research interests include deciphering the signaling pathways of G-protein coupled receptor (GPCR) in human cells, with an emphasis on GPCR signaling in developmental biology. My lab will employ the cutting-edge technologies in GPCR area and leverage extensive collaborations with other research groups to explore the critical involvement of GPCRs in embryogenesis and tissue homeostasis regulation, and the direct relevance of dysregulation of GPCR signaling to numerous human diseases.
bookSelected Publications

1. Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B, Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis for allosteric regulation of GPCRs by sodium ions” Science, 337(6091): 232-236, (2012)

2. Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J, Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors” Structure, 20(6): 967-976, (2012)

3. Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, Stevens R.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5’ -Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment-Based Searching” J Med Chem, 55(9): 4297-4308, (2012)

4. Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C, Jacobson K.A. “Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor” J Med Chem, 55(1): 538-552, (2012)

5. Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocket” Structure, 19(9): 1204-1207, (2011) Invited Review.

6. Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, Stevens R.C. “Structure of an agonist-bound human A2A adenosine receptor” Science, 332: 322-327, (2011)

7. Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases” Crystal Growth & Design, 11(4): 1193-1201, (2011)

8. Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog GA, Teng M, Niu L. “Core structure of the yeast Spt4-Spt5 complex: a conserved module for regulation of transcription elongation”Structure, 16:1649-1658, (2008)