Houchao Tao Research Associate Professor

InstituteiHuman Institute
Research AreaChemistry and Chemical Biology
Contacttaohch@shanghaitech.edu.cn, WebPage

1999, B.S in Chemistry, Nankai University;

2002, M.S in Organic chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences;

2007, Ph.D in Chemistry, The Scripps Research Institute, La Jolla, CA, USA

2014, Research associate professor, iHuman Institute, ShanghaiTech University

helix2Research Interests
Chemical tool and methodology development for the structural and functional study of GPCR;

Diagnostic and therapeutic agent development for specific GPCR targeting disease

bookSelected Publications
  1. Tao, H.†, Lee, S.C.†, Moeller, A.†, Roy, R.S., Siu, F.-Y., Zimmermann, J., Stevens, R.C., Potter, C.S., Carragher, B., Zhang, Q.*, Engineered nanostructured β-sheet peptides protect integral membrane proteins as stable and functional single particles. Nature Methods, 2013, 10, 759-761.

  2. Marcoux, J., Wang, S., Politis, A., Reading, E., Ma, J., Biggins, P., Zhou, M., Tao, H., Zhang, Q., Chang, G., Morgner, N.*, Robinson, C.V.*, Mass spectrometry reveals synergistic binding of nucleotides, lipids and drugs to a multidrug resistance efflux pump. Proc. Natl. Acad. Sci. USA 2013, 110, 9704-9709.

  3. Tao, H., Fu, Y., Thompson A., Lee, S.C., Mahoney, N., Stevens, R.C., Zhang, Q.*, Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies. Langmuir 2012, 28, 11173-11181.

  4. Tao, H., Weng, Y., Zhuo, R., Chang, G., Urbatsch, I.L., Zhang, Q.*, Design and synthesis of selenazole-containing peptides for co-crystallization with P-glycoprotein. ChemBioChem. 2011, 12, 868-873.

  5. Elliott I.G., Fuchs, J.R., Blagg, B.S.J., Ishikawa, H., Tao, H., Yuan, Z.-Q., Boger, D.L.*, Intramolecular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-Oxadiazoles. J. Am. Chem. Soc. 2006, 128, 10589-10595.

  6. Tao, H., Huang, I., and Boger, D.L.*, Multidrug resistance reversal activity of permethyl ningalin B amide derivatives. Bioorg. Med. Chem. Lett. 2004, 14, 5979-5981;

  7. Yu, B.* and Tao, H., Glycosyl trifluoroacetimidates. 2. Synthesis of Dioscin and Xiebai Saponin I. J. Org. Chem. 2002, 67, 9099-9102;