Raymond Stevens Professor, Founding Director

InstituteiHuman Institute
Research AreaMolecular Structural Biology and Drug Discovery
Contactstevens@shanghaitech.edu.cn     Webpage

B.A. Chemistry, University of Southern Main, 1986
Ph.D. Organic Chemistry, University of South California, 1988
Postdoctoral Fellow, Chemistry, Harvard University, 1992
Assistant Professor of Neurobilogy, University of California, Berkeley, 1994-1999
Senior Principal Investigator, Lawrence Berkeley National Laboratory, 1993-2001
Professor of Molecular Biology and Chemistry, The Scripps Research Insitute, 1999-2014
Provost Professor, University of Southern California 2014-present
Founding Director, iHuman Institute, 2012-present
bookSelected Publications
  1. V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, R.C. Stevens “High resolution crystal structure of human β2-adrenergic G protein coupled receptor” (cover story) Science 318, 1258-1265 (2007). PMC2583103.

  2. D.M. Rosenbaum, V. Cherezov, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, X.-J. Yao, W.I. Weis, R.C. Stevens, B.K. Kobilka “GPCR engineering provides high resolution structural insights into the function of the β2-adrenergic receptor” Science 318, 1266-1273 (2007).

  3. V.P. Jaakola, M.T. Griffith, M.A. Hanson, V. Cherezov, E.Y.T. Chien, J.R. Lane, A.P. IJzerman, R.C. Stevens. “The 2.6Å crystal structure of a human A2A adenosine receptor bound to an antagonist.” Science, 322, 1211-1217 (2008).PMC2586971.

  4. L.G. Holden, C. Prochnow, Y.P. Chang, R. Bransteitter, L. Chelico, U. Sen, R.C. Stevens, M.F. Goodman, X.S. Chen. “Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.”Nature 456, 121-124 (2008).PMC2714533.

  5. B. Wu, E.Y.T. Chien, C.D. Mol, G. Fenalti, W. Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, F.C. Bi, D.J. Hamel, P. Kuhn, T.M. Handel, V. Cherezov, R.C. Stevens “Structures of the CXCR4 chemokine GPCR with small molecule and cyclic peptide antagonists” Science 330, 1066-1071 (2010). PMC3074590.

  6. E.Y.T. Chien, W. Liu, Q. Zhao, V. Katritch, G.W. Han, M.A. Hanson, L. Shi, A.H. Newman, J.A. Javitch, V. Cherezov, R.C. Stevens “Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist” Science 330, 1091-1095 (2010). PMC3058422.

  7. F. Xu, H. Wu, V. Katritch, G.W. Han, K.A. Jacobson, Z.-G. Gao, V. Cherezov, R.C. Stevens “Structure of an agonist-bound human A2A adenosine receptor” Science 332, 322-327 (2011). PMC3086811.

  8. T. Shimamura, M. Shiroishi, S. Weyand, H. Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, W. Liu, G.W. Han, T. Kobayashi, R.C. Stevens, S. Iwata. “Structure of the human histamine H1 receptor in complex with doxepin” Nature 475, 65-70 (2011). PMC3131495.

  9. J.J. Liu, R. Horst, V. Katritch, R.C. Stevens, K. Wüthrich. “Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR” Science 335, 1055-1056 (2012). PMC3292700.

  10. M.A. Hanson, C.B. Roth, E. Jo, M.T. Griffith, F.L. Scott, G. Reinhart, H. Desale, B. Clemons, S.M. Cahalan, S.C. Schuerer, M.G. Sanna, G.W. Han, P. Kuhn, H. Rosen, R.C. Stevens. “Crystal structure of a lipid G protein-coupled receptor” Science 335, 851-855 (2012).PMC3338336.

  11. H. Wu, D. Wacker, M. Mileni, V. Katritch, G.W. Han, E. Vardy, W. Liu, A.A. Thompson, X.-P. Huang, F.I. Carroll, S.W. Mascarella, R.B. Westkaemper, P.D. Mosier, B.L. Roth, V. Cherezov, R.C. Stevens. “Structure of the human kappa opioid receptor in complex with JDTic” Nature485, 327-332 (2012). PMC3356457.

  12. A.A. Thompson, W. Liu, E. Chun, V. Katritch, E. Vardy, H. Wu, C. Trapella, X.-P. Huang, R. Guerrini, G. Calo, B.L. Roth, V. Cherezov, R.C. Stevens “Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic” Nature,485, 395-399 (2012). PMC3356928.

  13. W. Liu, E. Chun, A.A. Thompson, P. Chubukov, F. Xu, V. Katritch, G.W. Han, C.B. Roth, L.H. Heitman, A.P. IJzerman, V. Cherezov, R.C. Stevens “Structural basis for allosteric regulation of GPCRs by sodium ions” Science 337, 232-236 (2012). PMC3399762.

  14. C. Wang, Y. Jiang, J. Ma, H. Wu, D. Wacker, V. Katritch, G.W. Han, W. Liu, X.-P. Huang, E. Vardy, J.D. McCorvy, X. Gao, E.X. Zhou, K. Melcher, C. Zhang, F. Bai, H. Yang, L. Yang, H. Jiang, B.L. Roth, V. Cherezov, R.C. Stevens, H.E. Xu. “Structural basis for molecular recognition at serotonin receptors” Science, 340, 610-614 (2013).PMC3644373.

  15. D. Wacker, C. Wang, V. Katritch, G.W. Han, X.-P. Huang, E. Vardy, J.D. McCorvy, Y. Jiang, M. Chu, F.Y. Siu, W. Liu, H.E. Xu, V. Cherezov, B.L. Roth, R.C. Stevens. “Structural features for functional selectivity at serotonin receptors” Science, 340, 615-619 (2013). PMC3644390.

  16. C. Wang, H. Wu, V. Katritch, G.W. Han, X.P. Huang, W. Liu, F.Y. Siu, B.L. Roth, V. Cherezov, R.C. Stevens “Structure of the human smoothened receptor bound to an antitumor agent” Nature, 497, 338-43 (2013). PMC3657389.

  17. F.Y. Siu, M. He, C. de Graaf, G.W. Han, D. Yang, Z. Zhang, C. Zhou, Q. Xu, D. Wacker, J.S. Joseph, W. Liu, J. Lau, V. Cherezov, V. Katritch, M.W. Wang, R.C. Stevens “Structure of the human glucagon class B G-protein-coupled receptor” Nature 499, 444-9 (2013). PMC3820480.

  18. Q. Tan, Y. Zhu, J. Li, Z. Chen, G.W. Han, I. Kufareva, T. Li, L. Ma, G. Fenalti, J. Li, W. Zhang, X. Xie, H. Yang, H. Jiang, V. Cherezov, H. Liu, R.C. Stevens, Q. Zhao, B. Wu. “Structure of the CCR5 chemokine receptor – HIV entry inhibitor Maraviroc complex” Science, 341, 1387-90 (2013).PMC3819204.

  19. W. Liu, D. Wacker, C. Gati, G.W. Han, D. James, D. Wang, G. Nelson, U. Weierstall, V. Katritch, A. Barty, N.A. Zatsepin, D. Li, M. Messerschmidt, S. Boutet, G.J. Williams, J.E. Koglin, M.M. Seibert, C. Wang, S.T.A. Shah, S. Basu, R. Fromme, C. Kupitz, K.N. Rendek, I. Grotjohann, P. Fromme, R.A. Kirian, K.R. Beyerlein, T.A. White, H.N. Chapman, M. Caffrey, J.C.H. Spence, R.C. Stevens, V. Cherezov “Serial femtosecond crystallography of G protein-coupled receptors” Science 342, 1521-1524 (2013). PMC3902108.

  20. I. Coin, V. Katritch, T. Sun, Z. Xiang, F.Y. Siu, M. Beyermann, R.C. Stevens, L. Wang. “Genetically encoded chemical probes in cells reveal the binding path of Urocortin-I to CRF class B GPCR” Cell 155, 1258-1269 (2013).PMC3916339.

  21. G. Fenalti, P.M. Giguere, V. Katritch, X.P. Huang, A.A. Thompson, V. Cherezov, B.L. Roth, R.C. Stevens “Molecular control of δ-opioid receptor signaling. Nature, 506, 191-196 (2014).PMC3931418.

  22. H. Wu, C. Wang, K. J. Gregory, G. W. Han, H. P. Cho, Y. Xia, C. M. Niswender, V. Katritch, J. Meiler, V. Cherezov, P. J. Conn, R. C. Stevens “Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator”Science, 344, 58-64 (2014). PMC3991565.

  23. K. Zhang, J. Zhang, Z.-G. Gao, D. Zhang, L. Zhu, G.W. Han, S.M. Moss, S.Paoletta, E.Kiselev, W. Lu, G.Fenalti, W. Zhang, C.E. Müller, H. Yang, H. Jiang, V. Cherezov, V. Katritch, K.A. Jacobson, R.C. Stevens, B. Wu, Q. Zhao “Structure of the human P2Y12R receptor in complex with an antithrombotic drug” Nature509, 115-118, (2014).NIHMSID: 560848.

  24. J. Zhang, K. Zhang, Z.-G. Gao, S. Paoletta, D. Zhang, G.W. Han, T. Li, L. Ma, W. Zhang, C.E. Müller, H. Yang, H. Jiang, V. Cherezov, V. Katritch, K.A. Jacobson, R.C. Stevens, B. Wu, Q. Zhao. “Agonist-bound structure of the human P2Y12 receptor” Nature 509, 119-122 (2014).NIHMSID: 580843.