Wenqing Shui Research Associate Professor

InstituteiHuman Institute
Research AreaBio-mass spectrometry and Quantitative Biology

Dr. Wenqing Shui graduated from Fudan University (Shanghai, China) with a master degree in 2004 and received Ph.D. at University of California (Berkeley, U.S.A.) with Dr. Carolyn Bertozzi and Dr. Jay Keasling in 2009. After her postdoctoral training at Thermo Fisher Scientific (San Jose, USA) as a bio-mass spectrometry application scientist, she joined School of Life Sciences in Nankai University (Tianjin, China) as Associate Professor from 2010 to 2015. During 2013-2015,she was Joint PI at Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of Sciences. Then she joined TIB as PI from 2015 to 2016. Since April 2016, she joined ShanghaiTech university as an assistant professor at school of life science and technology and as a research associate professor(PI) at iHuman institute.
helix2Research Interests
The main goal of Shui research group is to develop versatile mass spectrometry (MS)-based technologies for GPCR ligand discovery and cell signaling study. Over the years, our group has gained extensive experiences in developing high resolution mass spectrometry-centered analytical pipelines for comprehensive or targeted protein and metabolite analysis. Our expertise in proteomics and metabolomics research has been exploited to establish affinity mass spectrometry technology for ligand screening towards protein targets of therapeutic importance. These new approaches have unique advantages in building a high-throughput screening platform for early-phase drug discovery as well as probing receptor-drug interactions and signaling selectivity within the cell.
bookSelected Publications

1.Li Z, Li Y, Chen W, Cao Q, Guo Y, Wan N, Jiang X, Tang YJ, Wang Q, Shui W*. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis. Anal Chem. 2016 Dec 14. [Epub ahead of print]

2. Fu X, Wang Z, Li L, Dong S, Li Z, Jiang Z, Wang Y, Shui W*. Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches. Sci Rep. 2016 Jul 12;6:29680.

3. Y, Guo Y, Xiao W, Cao Q, Li S, Qi X, Zhang Z, Wang Q*, Shui W*. An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry. Analytical Chemistry 2016 Feb 8. [Epub ahead of print]

4. Liu N, Xiong Y, Li S, Ren Y, He Q, Gao S, Zhou J*, Shui W*. New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry. Scientific Reports 2015, 5, 16869.

5. Liu N, Xiong Y, Ren Y, Zhang L, He X, Wang X, Liu M, Li D, Shui W*, Zhou J*. Proteomic Profiling and Functional Characterization of Multiple Post-translational Modifications of Tubulin. Journal of Proteome Research 2015, 14, 3292-3304.

6. Shui W*, Xiong Y, Xiao W, Qi X, Zhang Y, Lin Y, Guo Y, Zhang Z, Wang Q*, Ma Y. Understanding the mechanism of thermotolerance distinct from heat shock response through proteomic analysis of industrial strains of Saccharomyces cerevisiae. Molecular & Cellular Proteomics 2015, 14, 7, 1885-1897.

7. Chen X, Qin S, Chen S, Li J, Li L, Wang Z, Wang Q, Lin J, Yang C, Shui W*. A Ligand-observed Mass Spectrometry Approach Integrated into the Fragment Based Lead Discovery Pipeline. Scientific Reports 2015, 5, 8361.

8. Chen X, Li L, Chen S, Xu Y, Xia Q, Guo Y, Liu X, Tang Y, Zhang T, Chen Y, Yang C*, Shui W*. Identi?cation of Inhibitors of the Antibiotic-Resistance Target New Delhi Metallo-β-lactamase 1 by both Nanoelectrospray Ionization Mass Spectrometry and Ultrafiltration-LC/MS Approaches. Analytical Chemistry 2013, 85, 7957-7965.

9. Yan L, Ma Y, Liu D, Wei X, Sun Y, Chen X, Zhao H, Zhou J, Wang Z, Shui W*, Lou Z*. Structural basis for the impact of phosphorylation on plant receptor-like kinase BAK1 activation. Cell Research 2012, 8, 1304-1308.

10. Shui W, Sheu L, Liu J, Smart B, Keasling J, Bertozzi C. Membrane Proteomics of Phagosomes Suggests a Connection to Autophagy. PNAS 2008, 105, 16952-16957.