Teacher

Zhi-Jie Liu Professor, Deputy Director

Publishtimes:2017-08-23Views:26设置

InstituteiHuman Institute
Research AreaMolecular Structural Biology
Contactliuzhj@shanghaitech.edu.cn
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hat26Biography

1980-1984 B.Sc. in Physics, Tianjin Normal University, China
1984-1987 M.Sc. in Quantum Chemistry and Physical Chemistry, Tianjin Normal University
1987-1991 Lecturer, Tianjin Normal University
1991-1995 Ph.D. in Protein Crystallography, Institute of Biophysics, Chinese Academy of Sciences
1995-1995 Postdoctoral Fellow, Department of Crystallography, University of Pittsburgh
1995-1997 Postdoctoral Fellow, Department of Biochemistry & Molecular Biology, University of Georgia
1997-2002 Assistant Research Scientist, Department of Biochemistry & Molecular Biology, University of Georgia
2002-2005 Associate Research Scientist, Department of Biochemistry & Molecular Biology, University of Georgia
2005-2013 Professor, Institute of Biophysics, Chinese Academy of Sciences
2013 – present Professor, iHuman Institute, ShanghaiTech University
helix2Research Interests
(1) Structural and functional analysis of human cell signaling;  (2) Structure based drug discovery on human cell signaling relevant proteins;  (3) Methodology and technology development on X-ray crystallography.
bookSelected Publications

1. Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. (2017) Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature, doi: 10.1038/nature23272.

2. Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F,5,6, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC. (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, doi: 10.1038/nature22378

3. Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, Kufareva I, Wu B, Zhao Q, Hanson MA, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, doi: 10.1016/j.cell.2016.10.004

4. Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. (2016) Structural basis for DNA recognition by STAT6. PNAS, doi: 10.1073/pnas.1611228113.

5. Batyuk A, Galli L, Ishchenko A, Han GW, Gati C, Popov PA, Lee MY, Stauch B, White TA, Barty A, Aquila A, Hunter MS, Liang M, Boutet S, Pu M, Liu ZJ, Nelson G, James D, Li C, Zhao Y, Spence JC, Liu W, Fromme P, Katritch V, Weierstall U, Stevens RC, Cherezov V. (2016) Native Phasing of X-ray Free Electron Laser data for a G protein-coupled receptor. Science Advances, doi: 10.1126/sciadv.1600292

6. Lv X, Liu J, Shi Q, Tan Q, Wu D, Skinner JJ, Walker AL, Zhao L, Gu X, Chen N, Xue L, Si P, Zhang L, Wang Z, Katritch V, Liu ZJ, Stevens RC. (2016) In vitro expression and analysis of the 826 human G protein-coupled receptors. Protein Cell, doi: 10.1007/s13238-016-0263-8

7. Gu J, Feng Y, Feng X, Sun C, Lei L, Ding W, Niu F, Jiao L, Yang M, Li Y, Liu X, Song J, Cui Z, Han D, Du C, Yang Y, Ouyang S, Liu ZJ, Han W. (2014) Structural and biochemical characterization reveals LysGH15 as an unprecedented EF-hand-like calcium-binding phage lysin. PLOS Pathogens, doi: 10.1371/journal.ppat.1004109

8. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting JP. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immunesignaling induced by the DNA sensor STING. Immunity, doi: 10.1016/j.immuni.2014.01.010

9. Natashin PV, Ding W, Eremeeva EV, Markova SV, Lee J, Vysotski ES, Liu ZJ.. (2014) Structures of the Ca2+-regulated photoprotein obelin Y138F mutant before and afterbioluminescence support the catalytic function of a water molecule in the reaction. Acta Crystallogr D Biol Crystallogr, doi: 10.1107/S1399004713032434

10. Won EY, Xie Y, Takemoto C, Chen L, Liu ZJ, Wang BC, Lee D, Woo EJ, Park SG, Shirouzu M, Yokoyama S, Kim SJ, Chi SW. (2013) High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26. Acta Crystallogr D Biol Crystallogr, doi: 10.1107/S0907444913004770

11. Jiao L, Ouyang S, Liang M, Niu F, Shaw N, Wu W, Ding W, Jin C, Peng Y, Zhu Y, Zhang F, Wang T, Li C, Zuo X, Luan CH, Li D, Liu ZJ. (2013) Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential. J. Virology, doi: 10.1128/JVI.00672-13

12. Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ. (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Research, doi: 10.1038/cr.2013.52

13. Niu F, Shaw N, Wang YE, Jiao L, Ding W, Li X, Zhu P, Upur H, Ouyang S, Cheng G, Liu ZJ. (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation. PNAS, doi: 10.1073/pnas.1300035110

14. Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.Nat Immunol, doi: 10.1038/ni.2460

15. Zhan Z, Ouyang S, Liang W, Zhang Z, Liu ZJ, Huang L. (2012) Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase. Acta Cryst, doi: 10.1107/S0907444912007202

16. Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ. (2012) The S-SAD phasing study of DR6 and its solution conformation revealed by SAXS. Acta Cryst, doi: 10.1107/S0907444912004490

17. Liu ZJ, Chen L, Wu D, Ding W, Zhang H, Zhou W, Fu ZQ, Wang BC. (2011) A multi-dataset data-collection strategy produces better diffraction data. Acta Crystallogr A, doi: 10.1107/S0108767311037469

18. Wu D, Li Y, Song G, Cheng C, Zhang R, Joachimiak A, Shaw N, Liu ZJ. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, doi: 10.1158/0008-5472.CAN-09-1927

19. Shaw N, Zhao M, Cheng C, Xu H, Saarikettu J, Li Y, Da Y, Yao Z, Silvennoinen O, Yang J, Liu ZJ, Wang BC, Rao Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, doi: 10.1038/nsmb1269

20. Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa-Suetsugu K, Akasaka R, Nishino Y, Toyama M, Chen L, Liu ZJ, Wang BC, Yamamoto M, Terada T, Miyazawa A, Tanaka A, Sugano S, Shirouzu M, Nagayama K, Takenawa T, Yokoyama S. (2007). Curved EFC/F-BAR domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell, doi: 10.1016/j.cell.2007.03.040

21. Liu ZJ, Stepanyuk GA, Vysotski ES, Lee J, Markova SV, Malikova NP, Wang BC. (2006). Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. PNAS, doi: 10.1073/pnas.0511142103

22. Liu ZJ, Tempel W, Ng JD, Lin D, Shah AK, Chen L, Horanyi PS, Habel JE, Kataeva IA, Xu H, Yang H, Chang JC, Huang L, Chang SH, Zhou W, Lee D, Praissman JL, Zhang H, Newton MG, Rose JP, Richardson JS, Richardson DC, Wang BC. (2005). The high-throughput protein-to-structure pipeline at SECSG. Acta Cryst D, doi: 10.1107/S0907444905013132

23. Liu ZJ, Lin D, Tempel W, Praissman JL, Rose JP, Wang BC. (2005) Parameter-space screening: a powerful tool for high-throughput crystal structure determination. Acta Cryst D, doi: 10.1107/S0907444905003239

24. Liu ZJ, Sun YJ, Rose J, Chung YJ, Hsiao CD, Chang WR, Kuo I, Perozich J, Lindahl R, Hempel J, Wang BC. (1997). The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold. Nat Struct Biol, 1997 Apr;4(4):317-26.


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