Jianjun Cheng Research Associate Professor


InstituteiHuman Institute
Research AreaMedicinal Chemistry
Contactchengjj@@shanghaitech.edu.cn, WebPage

2001.09 – 2005.06 B.S. in Pharmaceutical Sciences
College of Pharmacy, Shandong University (Jinan, Shandong)
2005.09 – 2010.07 Ph.D. in Medicinal Chemistry (Advisor: Yushe Yang)
Shanghai Institute of Materia Medica, CAS (Shanghai, China)
2010.07 – 2013.10 Senior Scientist, Department Director
Shanghai Huilun Life Science & Technology Co. Ltd (Shanghai, China)
2013.11 – 2016.03 Postdoctoral Research Associate (Advisor: Alan P. Kozikowski)
College of Pharmacy, University of Illinois at Chicago (Chicago, USA)
2016.03 – present Research Associate Professor, Principle Investigator
iHuman Institute, ShanghaiTech University (Shanghai, China)

helix2Research Interests

GPCR targeted drug design, synthesis, and development.

bookSelected Publications

1. Cheng, J.; Giguere, P. M.; Schmerberg, C. M.; Pogorelov, V. M.; Rodriguiz, R. M.; Huang, X.-P.; Zhu, H.; McCorvy, J. D.; Wetsel, W. C.; Roth, B. L.; Kozikowski, A. P.* Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists:  Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. J Med Chem201659, 578–591.

2. Cheng, J.; Kozikowski, A. P.* We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders. ChemMedChem ,201510, 1963–1967.

3. Cheng, J.; Giguere, P. M.; Onajole, O. K.; Lv, W.; Gaisin, A.; Gunosewoyo, H.; Schmerberg, C. M.;  Pogorelov, V. M.; Rodriguiz, R. M.; Giulio Vistoli, G.;  Wetsel, W. C.; Roth, B. L.; Kozikowski, A. P.* Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents. J Med Chem201558, 1992–2002.

4. Cheng, J.; Giguere, P. M.; Lv, W.; Roth, B. L.; Kozikowski, A. P.* Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)-methanamine as a Selective Serotonin 2C Agonist. Tetrahedron Lett201556, 3420–3422.

5. Cheng, J.*; Qin, J.; Guo, S.; Qiu, H.; Zhong, Y. Design, Synthesis and Evaluation of Novel HDAC Inhibitors as Potential Antitumor Agents. Bioorg Med Chem Lett ,201424, 4768–4772.

6. Cheng, J.; Liqiang Fu, L.; Chenyu Ling, C.; Yang, Y.* Total Synthesis of S-(–)-Stepholidine Using (S)-tert-Butanesulfinylimine. Heterocycles2010, 81, 2581–2592.

7. Cheng, J.-J.; Yang, Y.-S.* Enantioselective Total Synthesis of (–)-(S)-Stepholidine. J Org Chem, 2009, 74, 9225–9228.