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Publishtimes:2017-08-23Views:5设置

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A team of scientists led by Professor Zhi-jie Liu at the iHuman Institute of ShanghaiTech University has determined the 3-dimensional molecular structure of the agonist-bound human cannabinoid receptor CB1. The work reveals the structural features of agonist-bound CB1 and the activation mechanism of the receptor. The results, described in a paper entitled “Crystal structures of agonist-bound human cannabinoid receptor CB1”, published online on July 6, 2017 in the prestigious journal Nature.Read More ...
 
  • iHuman Institute at ShanghaiTech University and Amgen Asia R&D Center determine the High-resolution Human Apelin Receptor Structure

    iHuman Institute at ShanghaiTech University and Amgen Asia R&D Center determine the High-resolution Human Apelin Receptor Structure

    Shanghai, May 18, 2017 — An international team led by the Xu lab at the iHuman Institute of ShanghaiTech University and the Amgen Asia R&D Center have determined the crystal structure of the human apelin receptor (APJR) in complex with a 17-aa peptide agonist at 2.6 Å. The results provide a mechanistic understanding of apelin recognition and binding specificity to APJR. The results, described in a paper entitled “Structural basis for apelin control of the human apelin receptor” , is published on May 18, 2017 in Structure, Cell Press.Read More ...
     
  • Key Diabetes Receptor Structure Determined by International Collaboration—Shanghai Led Consortium Produces High Resolution 3D map of GLP-1R

    Key Diabetes Receptor Structure Determined by International Collaboration—Shanghai Led Consortium Produces High Resolution 3D map of GLP-1R

    SHANGHAI, May 17, 2017 — An international team led by the iHuman Institute, ShanghaiTech University has determined the 3-dimensional molecular structure of the human glucagon-like peptide-1 receptor (GLP-1R) drug binding domain. The work reveals molecular mechanisms of allosteric regulation in class B G protein-coupled receptors (GPCRs). The results, described in a paper entitled “Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators”, is published online on May 17, 2017 in the journal Nature. This paper is published simultaneously with a companion paper led by colleagues at the Shanghai Institute of Materia Medica (SIMM) describing the full-length glucagon receptor in the same journal.Read More ...
     
  • The iHuman Team at ShanghaiTech University Deciphers the Multi-domain Structure of Human Smoothened Receptor

    The iHuman Team at ShanghaiTech University Deciphers the Multi-domain Structure of Human Smoothened Receptor

    SHANGHAI, May 17, 2017 — A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fudan University has determined the high-resolution crystal structure of the multi-domain human smoothened receptor.  The results illustrate the allosteric domain-domain interactions within the receptor, and their role in smoothened activation. These new findings are published on May 17, 2017 in Nature Communications, titled “Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand” by Zhang X-J et al.Read More ...
     
  • iHuman Institute Scientific Research Selected as Shanghai Top Ten Science & Technology Stories for 2016

    iHuman Institute Scientific Research Selected as Shanghai Top Ten Science & Technology Stories for 2016

    January 9, 2017 - The Shanghai city government recently announced the 2016 Shanghai Top Ten Science & Technology stories. Included in the list is the structure of cannabinoid receptor 1 (CB1), also known as the “marijuana receptor” published in the prestigious international journal Cell in October, 2016.Read More ...
     
  • iHuman Institute Holds “2016 Science Day”

    iHuman Institute Holds “2016 Science Day”

    The iHuman Institute held its first annual "iHuman Science Day" on December 13, 2016 in the new “Ren” building. Given the rapid and strong growth of the institute, the special Science Day was created to increase communication across the institute and display all of the incredible scientific results.  Highlights for 2016 included the structure determination of the cannabinoid CB1 receptor published in the journal Cell and the successful recruitment of faculty in other imaging areas including super resolution imaging, animal imaging, electron microscopy.  Future recruitments will be in the area of MRI, chemistry, and biology.Read More ...
     
  • iHuman Institute Holds 4th Annual iHuman Forum at the New ShanghaiTech University Campus

    iHuman Institute Holds 4th Annual iHuman Forum at the New ShanghaiTech University Campus

    SHANGHAI, CHINA –November 5th-6th, 2016, the iHuman Institute at ShanghaiTech University held the 4th Annual iHuman Forum this past weekend. More than 330 representatives from leading academic institutions and pharmaceutical companies gathered to present and discuss cutting-edge progress in the field of human cell signaling and imaging across the scales.Read More ...
     
  • ShanghaiTech Scientists Resolve the Structure of the Human “Marijuana Receptor”

    ShanghaiTech Scientists Resolve the Structure of the Human “Marijuana Receptor”

    SHANGHAI, CHINA – October 20, 2016 - A team of scientists led by theiHuman Institute of ShanghaiTech University has determined and analyzed the high-resolution atomic structure of human cannabinoid receptor 1 (CB1), also known as the “marijuana receptor”. This new findings provide clues to understand why some drugs that interact with this receptor have had unexpectedly complex and sometimes harmful effects, while the utility of the crystal structure may provide inspiration for drug design toward refining efficacy and avoiding adverse effects.Read More ...
     
  • 5th Annual Shanghai iHuman Forum

    5th Annual Shanghai iHuman Forum

    Webpage: http://ihumanforum.shanghaitech.edu.cn/Read More ...
     
  • 9/2016 Prof. Hartmut Michel Visits ShanghaiTech and Delivers ShanghaiTech Lecture

    9/2016 Prof. Hartmut Michel Visits ShanghaiTech and Delivers ShanghaiTech Lecture

    As invited by Prof. Raymond Stevens, Founding Director, and Prof. Zhi-Jie Liu, Deputy Director of iHuman Institute, ShanghaiTech University, Prof. Hartmut Michel, Director of Max Planck Institute of Biophysics, Nobel Laureate in Chemistry in 1988 visited ShanghaiTech University on September 14, 2016 and delivered ShanghaiTech Lecture.  Dr. Jiang Ge, Associate Provost of ShanghaiTech awarded Prof. Michel the Certificate of ShanghaiTech Lecture.Read More ...
     
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